Isifo sikaCharcot yisifo esingelapheki. Isidakamizwa, i i-riluzole (i-Rilutek), kunganciphisa ukuqhubeka kwesifo ngendlela ethambile kuya emaphakathi.

Odokotela banikeza iziguli ezinokuphathwa kwezifo zezimpawu zazo. Imithi inganciphisa ubuhlungu bemisipha, amajaqamba noma ukuqunjelwa, isibonelo.

Izikhathi zokwelapha ngokomzimba zinganciphisa umphumela wesifo emisipha. Umgomo wabo uwukugcina amandla emisipha kanye nobubanzi bokunyakaza ngangokunokwenzeka, kanye nokwandisa umuzwa wenhlalakahle. I-occupational therapist ingasiza ngokusetshenziswa kwezinduku, i-walker (i-walker) noma isihlalo esinamasondo esinamanyuwali noma sikagesi; angabuye eluleke ngokwakhiwa kwekhaya. Izikhathi zokwelapha inkulumo nazo zingaba usizo. Inhloso yabo ukuthuthukisa ukukhuluma, ukunikeza izindlela zokuxhumana (ibhodi yezokuxhumana, ikhompyutha) nokunikeza izeluleko ngokugwinya nokudla (ukwakheka kokudla). Ngakho-ke ithimba lonke lochwepheshe bezempilo abahlangana eduze kombhede.

Ngokushesha lapho imisipha ehilelekile ekuphefumuleni ifinyelelwa, kuyadingeka, uma kudingekile, ukuba isiguli sibekwe usizo lokuphefumula, okuvame ukubandakanya i-tracheostomy.