Iqiniso lokuthi esikhathini esizayo esiseduze i-oncology ekugcineni izoyeka ukuba isigwebo, ososayensi baphinde baqala ukukhuluma. Ngaphezu kwalokho, okwakamuva okutholwe abacwaningi baseNyuvesi yaseNotre Dame (eSouth Bend, e-United States) kubonisa ukuthi impumelelo yangempela ingenzeka ngisho nasekwelapheni izinhlobo zomdlavuza eziyingozi kakhulu, eziqine kakhulu ekwelapheni okukhona.
Ukukhishwa kwabezindaba okuthunyelwe kusizindalwazi se-Medical Xpress kudingida izici ezithile ze-RIPK1 protein enzyme. Ungomunye wabahlanganyeli ohlelweni lwe-cell necrosis. Kodwa-ke, njengoba ososayensi betholile, le phrotheni ingavimbela ukuthuthukiswa kwama-neoplasms ayingozi kanye nokuvela kwama-metastases. Ngenxa yalokho, le nhlanganisela ingase ibe enye yezingxenye zezidakamizwa ezihloselwe ukwelapha izinhlobo eziyingozi kakhulu zomdlavuza.
Njengoba yaziwa njengomphumela wocwaningo, i-RIPK1 isiza ukwehlisa ukuba khona kwe-mitochondria kumaseli. Lawa ama-organelles anesibopho sokuqaliswa kokushintshaniswa kwamandla. Lapho inombolo yabo iyancipha, lokho okubizwa ngokuthi "ukucindezeleka kwe-oxidative" kuqala ukukhula. Inani elikhulu lezinhlobo ze-oxygen esebenzayo lilimaza amaprotheni, i-DNA kanye ne-lipids, ngenxa yalokho inqubo yokuzibhubhisa kwamangqamuzana iqala. Ngamanye amazwi, inqubo ye-necrosis noma i-cell apoptosis iyaqalwa.
Ososayensi bakhumbuza ukuthi i-necrosis iyinqubo ye-pathological lapho iseli ngokwayo libhujiswa, futhi ukukhululwa kokuqukethwe kwayo kwenzeka endaweni ye-intercellular. Uma ingqamuzana lifa ngokuvumelana nohlelo lwalo lofuzo, olubizwa ngokuthi i-apoptosis, khona-ke izinsalela zalo ziyasuswa ezicubu, eziqeda amathuba okuvuvukala.
Ngokusho kwabacwaningi baseMelika, i-RIPK1 ingaba enye yezinto ezibangela lokho okubizwa ngokuthi "i-controlled cell death" inqubo. Ngamanye amazwi, ingasetshenziswa njengesikhali "sokubhujiswa kwamaphuzu" - ukusebenzisa "iziteleka" ezihlosiwe esimila nge-enzyme yephrotheni. Lokhu kuzosiza ukumisa inqubo ye-metastasis nokwanda kwe-neoplasm.