La progesterone is a i-hormone ye-steroid edlala indima ebalulekile ikakhulukazi ngesikhathi sokufakwa nokuthuthukiswa kwe-a ukukhulelwa. Nokho, kubalulekile ngisho nangaphandle kokukhulelwa, ukuze kugcinwe umsebenzi wezitho zangasese.

Ikhiqizwa ikakhulukazi ngu i-ovary (ngaphandle kokukhulelwa) kanye placenta (kusukela enyangeni yesibili, ukuthatha izintambo emzimbeni ophuzi). Ngesikhathi sokukhulelwa, kuvumela ukufuduka kweqanda elivundisiwe esibelethweni, bese kusiza ukufakwa kwalo, phakathi kwezinye izinto.

Izinga le-progesterone egazini liyahlukahluka phakathi nomjikelezo wokuya esikhathini. Iphansi phakathi nesigaba se-follicular, ikhula kakhulu ngesikhathi se-luteal, ifinyelela ezinsukwini ezi-5 kuya kweziyi-10 ngemuva kokuhlinzwa kwe-LH (i-hormone ye-luteinizing, ebangela ukuvuthwa kweqanda). Amazinga abe esencipha, ngaphandle kokukhulelwa.

Egazini, i-progesterone ijikeleza eboshelwe kumaprotheni ahlukahlukene (i-transcortin, i-albumin ne-orosomucoid).

Umthamo we-progesterone yegazi (i-progestéronémie) kungenziwa ezimweni eziningana:

• phakathi kwe-20^st kanye ne-23^st usuku lokujikeleza kokuya esikhathini, ukuqinisekisa ukuthi i-corpus luteum ikhiqiza amanani ajwayelekile e-progesterone, adingekayo ekufakweni kokukhulelwa (uma kungabaza ngesikhathi sokuphuphuma kwezisu okuphindaphindiwe)
• emavikini okuqala okukhulelwa, ukuqinisekisa ukuthi iqhubeka kahle (izinga kufanele lihlale lizinzile)
• ukuhlola ukuphumelela kokungeniswa kwe-ovulation ekuzaleni okusizwa ngokwemithi
• ukuxilonga ukukhulelwa kwe-ectopic (ngokuhambisana nokuhlolwa kwe-hCG), i-progesterone ibe iphansi ngokungavamile
• esimweni sokuzala okusizwa ngokwemithi, ukuvundiswa kwe-in vitro kanye nokudluliselwa kombungu, noma ukuhlelwa kwe-intrauterine inseminations (kuwuphawu lokuphuma kweqanda)

Ukuhlolwa kwegazi kwenziwa ngesampula ye-venous, ngokuvamile ejikeni lendololwane. Akukho ukulungiswa okudingekayo, kodwa usuku lwenkathi yokugcina noma ukuqala kokukhulelwa kufanele kucaciswe.

Njengomhlahlandlela, amazinga egazi ajwayelekile we progesterone Ukukhulelwa kwangaphandle kungaphansi kuka-1,5 ng/mL ngesikhathi sesigaba se-follicular, phakathi kuka-0,7 no-4 ng/mL ngesikhathi sokuvuthwa okuphezulu kanye naphakathi kuka-2 no-30 ng/mL ngesikhathi se-luteal (ukubonisa ubukhona be-ovulation). i-corpus luteum).

Ziyancipha at the menopause.

Ngesikhathi sokukhulelwa, ngo-5st isonto lei-amenorrhea, zingaba ngu-40 ng / mL futhi zifinyelela ku-200 ng / mL ekupheleni ukukhulelwa.

Lapho kutholwa amazinga aphansi e-progesterone aphansi ngokungavamile, ikakhulukazi kowesifazane ofisa ukukhulelwa, ukwesekwa kungase kucatshangelwe engxenyeni yesibili yomjikelezo.

Ekugcineni, phawula ukuthi i- i-progestéronémie kungase kwandiswe kuma-pathologies amaningana, ikakhulukazi amathumba athile e-ovarian noma ama-adrenal noma ukusilela okuthile kokuzalwa.

Udokotela kuphela ozokwazi ukuhumusha imiphumela futhi enze ukuxilongwa, ngezinye izikhathi ngosizo lokuhlolwa okwengeziwe noma ukuhlaziya.