Ezimweni eziningi (ngaphezu kwama-95%), i-hypersecretion ye-hormone yokukhula ebangela i-acromegaly ihlobene nokuthuthukiswa kwe-benign pituitary tumor (pituitary adenoma), indlala encane (cishe ubukhulu be-chickpea), etholakala ngezansi. yobuchopho, cishe ukuphakama kwekhala.

Lesi simila sivame ukwenzeka ngokungalindelekile: bese sifaneleka njenge "sporadic". Kwezinye, izimo ezingavamile kakhulu, i-acromegaly ixhunywe ku-genetic anomaly: kukhona ezinye izimo emndenini futhi zingahlotshaniswa namanye ama-pathologies.

Noma kunjalo, ukuphikiswa phakathi kwezinhlobo ze-sporadic kanye nezinhlobo zomndeni kunzima nakakhulu ukulondoloza, njengoba nje, emafomu angavamile (ngaphandle kwamanye amacala emndenini), muva nje kungenzeka ukukhombisa ukuthi kukhona nokuguqulwa kofuzo. emsuka wesifo.