Udokotela wokubelethisa owaziwa ngokugxila kwakhe nasekucwaningeni ngokukhulelwa okuningi wathola ukuthi izinguquko zokudla zingaphazamisa amathuba wesifazane okuba namawele, nokuthi amathuba ewonke anqunywa inhlanganisela yokudla kanye nemfuzo.
Ngokuqhathanisa amanani amawele abesifazane abadla inyama abangayidli imikhiqizo yezilwane nabesifazane abadla imikhiqizo yezilwane, uDkt. Gary Steinman, udokotela wezisebenzi e-Long Island Jewish Medical Center eNew Hyde Park, eNew York, uthole ukuthi imikhiqizo yabesifazane, ikakhulukazi yobisi. imikhiqizo, kunamathuba aphindwe kahlanu okuba namawele. Ucwaningo lwashicilelwa kumagazini kaMeyi 20, 2006 weJournal of Reproductive Medicine.
I-Lancet ishicilele ukuphawula kukaDkt. Steinman mayelana nemiphumela yokudla kumawele kumagazini wayo wangomhla ziyisi-6 kuNhlaba.
Icala lingase libe yi-insulin-like growth factor (IGF), iphrotheni ekhishwa esibindini sezilwane - kuhlanganise nabantu - ngokuphendula i-hormone yokukhula, ijikeleza egazini, futhi idlulele obisini. I-IGF ikhulisa ukuzwela kwama-ovari ku-follicle-stimulating hormone, ikhulisa i-ovulation. Ezinye izifundo zisikisela ukuthi IGF ingasiza imibungu ukusinda ezigabeni zokuqala zokukhula. Ukuhlushwa kwe-IGF egazini labesifazane be-vegan cishe ku-13% ephansi kunaleyo yabesifazane abadla imikhiqizo yobisi.
Izinga elingamawele e-US likhuphuke kakhulu kusukela ngo-1975, mayelana nesikhathi ubuchwepheshe bokuzala obusizayo (ART) okwethulwa ngaso. Ukuhlehlisa ukukhulelwa ngamabomu nakho kube neqhaza ekwandeni kokukhulelwa kaningi, njengoba amathuba wesifazane okuba namawele akhula ngokuya ngeminyaka ngisho nangaphandle kwe-ART.
"Ukukhula okuqhubekayo kwamawele ku-1990, noma kunjalo, kungase futhi kube umphumela wokwethulwa kwe-hormone yokukhula ezinkomeni ukuze kuthuthukiswe ukusebenza," kusho uDkt. Steinman.
Ocwaningweni lwamanje, lapho uDkt. Steinman eqhathanisa amanani angamawele abesifazane abadla ngokujwayelekile, abadla imifino abadla ubisi, kanye nezilwane ezidla inyama, uthole ukuthi ama-vegan azala amawele izikhathi eziphindwe kahlanu kunabesifazane abangalushiyi ngaphandle ubisi ekudleni kwabo.
Ngaphezu komphumela wokudla okunomsoco emazingeni e-IGF, kukhona isixhumanisi sofuzo ezinhlobonhlobo zezilwane eziningi, kuhlanganise nabantu. Ezinkomeni, izingxenye zekhodi yofuzo ezibhekene nokuzalwa kwamawele ziseduze ne-IGF gene. Abacwaningi benza ucwaningo olukhulu lwabesifazane base-Afrika-baseMelika, abamhlophe, nabase-Asia futhi bathola ukuthi amazinga e-IGF ayephakeme kakhulu kwabesifazane base-Afrika-American futhi aphansi kakhulu kwabesifazane base-Asia. Abanye besifazane bahlelwa ngokofuzo ukukhiqiza i-IGF eningi kunabanye. Kulezi zibalo zabantu, igrafu yamaphuzu amabili ihambisana negrafu yeleveli ye-FMI. “Lolu cwaningo lubonisa ngokokuqala ngqá ukuthi ithuba lokuba namawele linqunywa kokubili ufuzo nendawo ezungezile, noma, ngamanye amazwi, imvelo nokudla,” kusho uDkt. Steinman. Le miphumela iyafana naleyo ebonwa abanye abacwaningi ezinkomeni, okungukuthi: ithuba lokuzala amawele lihambisana ngqo nezinga lokukhula kwe-insulin egazini lowesifazane.
“Ngenxa yokuthi ukukhulelwa kwezingane eziningi kujwayele ukuba nezinkinga ezinjengokuzalwa ngaphambi kwesikhathi, ukukhubazeka, nomfutho wegazi ophakeme komama kunokukhulelwa kwe-singleton, imiphumela yalolu cwaningo iveza ukuthi abesifazane abacabanga ukukhulelwa kufanele bacabangele ukushintsha inyama nemikhiqizo yobisi bafake eminye imithombo yamaprotheni, ikakhulukazi emazweni. lapho ama-hormone okukhula evunyelwa ukuba anikezwe izilwane,” kusho uDkt. Steinman.
UDkt. Steinman ubefunda izici zokuzalwa ezingamawele kusukela athola amawele amane afanayo ngo-1997 e-Long Island EMC. Ucwaningo lwakhe lwakamuva, olushicilelwe kule nyanga kwi-Journal of Reproductive Medicine, mayelana namawele angabafowabo, lungolwesikhombisa ochungechungeni. Eziyisithupha ezisele, ezishicilelwe kujenali efanayo, zigxile kumawele afanayo noma afanayo. Isifinyezo seminye yemiphumela sinikezwe ngezansi.
Ucwaningo Olwedlule
UDkt Steinman uthole ukuthi abesifazane abakhulelwa bencelisa banamathuba aphindwe kayisishiyagalolunye okukhulelwa amawele kunalabo abangancelisi ngesikhathi bekhulelwe. Uphinde waqinisekisa ucwaningo olwenziwa ngabanye ososayensi olubonisa ukuthi amawele afanayo avame kakhulu emantombazaneni kunabafana, ikakhulukazi phakathi kwamawele ahlangene, nokuthi amawele afanayo anamathuba amaningi okuphuphunyelwa yizisu kunamawele.
UDkt. Steinman, esebenzisa izigxivizo zeminwe, wathola ubufakazi bokuthi njengoba inani lemibungu efanayo likhula, ukuhluka kwazo ngokomzimba kuyanda. Ocwaningweni lwakamuva mayelana nezinqubo zokuzalwa kwamawele, uDkt. Steinman ukuqinisekisile ukuthi ukusetshenziswa kwe-in vitro fertilization (IVF) kwandisa amathuba okuba namawele afanayo: ukufakelwa imibungu emibili kuzala abantwana abathathu, uphinde waphakamisa ukuthi ukwanda kwe-calcium. noma ukuncipha kwenani le-agent chelating - ethylenediaminetetraacetic acid (EDTA) endaweni ye-IVF kunganciphisa ingozi yezinkinga ezingadingeki.