Le i-fibrinogen is a amaprotheni igazi elidlala indima ukwanda. Ubamba iqhaza ekuqeqeshweni kwe amahlule igazi futhi iphinde iguqule umsebenzi we-platelet yegazi kanye iseli we imikhumbi. Ngaphansi kwesenzo senye amaprotheni, i i-thrombin, iphenduka i-fibrin

Ihlanganiswa ngamaseli esibindi. Izinga layo egazini livame ukuhluka kusuka ku-2 kuya ku-4 g / l. Nokho, synthesis lokhu amaprotheni kungase kwande ngenxa yokucindezeleka, ngesikhathi sokukhulelwa, noma ngemva kokujova imithi ethile noma i-hormone yokukhula. Ukwanda kwezinga le-fibrinogen egazini nakho kubonisa isimo sokuvuvukala.

I-fibrinogen assay ikhonjiswe ukuze ihlole ukuphazamiseka kokujiyisa kwegazi (isibonelo uma kwenzeka ukopha okungachazwanga noma ” i-defibrination syndrome », Okuhambisana nokungajwayelekile kwe-coagulation).

Kunezinkinga ezintathu zokuzalwa emazingeni e-fibrinogen:

• THEi-afibrinogenemia, okuwukungabikho ngokuphelele kwe-fibrinogen. Lesi sifo esingavamile sibangela ukopha okukhulu okuvela ekuzalweni
• THEhypofibrinogenemia, okuhambisana nokuncipha kwezinga le-fibrinogen egazini (lokhu kuyisici ekusithekeni, kaningi)
• La i-dysfibrinogenemia, okuwukungajwayelekile kwamaprotheni.

Ukuhlolwa kwe-blood fibrinogen nakho kungaba wusizo ezimeni:

• ukuvuvukala syndrome
• ukwehluleka kwesibindi (okuholela ekwehleni kwamazinga e-fibrinogen)
• ukuqapha umphumela wokwelashwa okubizwa ngokuthi "i-fibrinolytic", okuhloswe ngayo ukuhlakaza ihlule legazi uma kwenzeka i-thrombosis.

Umthamo we i-fibrinogen kwenziwa ngesampula yegazi le-venous (ukuhlolwa kwegazi), elabhorethri yokuhlaziywa kwezokwelapha. Umthamo ukulinganisa okuvamile futhi imiphumela ngokuvamile itholakala phakathi nosuku.

Udokotela nguyena kuphela ongahumusha imiphumela yokuhlaziywa.

Imvamisa, ukweqisa kwe-fibrinogen (i-hyperfibrinogenemia) ingabonwa uma kwenzeka ukuvuvukala, uma kunezifo ezithile ezithathelwanayo (i-pneumonia, njll.), Uma kwenzeka umkhuhlane we-rheumatic noma izifo ezizimele (lupus), ngemuva kwe-myocardial infarction, njll.

Ngokuphambene, i-hypofibrinogenemia (ukuncipha kwezinga le-fibrinogen) ingase ibonise isifo sofuzo, ukwehluleka kwesibindi okukhulu (i-hepatitis, i-cirrhosis), ukuphazamiseka kwe-coagulation (i-disseminated intravascular coagulation noma i-defibrination syndrome) noma "i-fibrinolysis", isibonelo ngenxa yomdlavuza.