Feb. 24, 2012 - Ngenkathi isetshenziswa kabanzi, izidakamizwa ezingezona ukuvuvukala (ama-NSAID) zibonakala ziveza ingozi yangempela empilweni. Phakathi kwezinto ezaziwa kakhulu kukhona i-aspirin, i-Advil®, i-Antadys®, i-Ibuprofen® noma iVoltarene®, izidakamizwa ezivame ukunikezwa.

Lesi sigaba semithi elwa nokuvuvukala kucatshangwa ukuthi singaba yingozi enhliziyweni nasezinsweni. Ngempela, ama-NSAID abanjelwe umthwalo walokhu:

• Izifo zenhliziyo

Ukwehlisa izinhlungu, izidakamizwa ezingezona ukuvuvukala ezivimbela ukusebenza kwama-enzyme amabili (= amaprotheni avumela isenzo se-biochemical) esibizwa nge-COX-1 ne-COX-2.

Ukuvimbela i-COX-2 ngama-NSAID kuvimbela ukujiya kwegazi kanye nokuhlanganiswa kwama-thromboxanes, ama-hormone anendima ye-vasoconstrictor, ngaleyo ndlela kukhuphule umfutho wegazi nobungozi benhliziyo.

• Izilonda nokopha endaweni yokugaya ukudla

I-COX-1 ivumela ukwakheka kwama-prostaglandin, ama-metabolites akhiqizwa ebuchosheni, ezinso nasenhliziyweni. Ukuvinjelwa kwe-COX-1 ngemithi elwa nokuvuvukala okungekho emthethweni kuvele kuyivimbele ekuvikeleni umgudu wokugaya ukudla, futhi ngaleyo ndlela kungadala isilonda esikhulukazi.

• Ukwehluleka kwezinso

Lokhu kuvinjelwa kwe-COX-1 kuzophinde kukhuthaze ukwehluleka kwezinso ngokunciphisa ukuthamba kwenso.

Ngokuvamile, ngabantu asebekhulile abakhathazeke kakhulu ngalezi zingozi, ngoba ukusebenza kwabo kwezinso kuyancipha, kuyindida, lapho sazi ukuthi imishanguzo elwa nokuvuvukala ibekwe kabanzi ukunqanda ubuhlungu obuhambisana ne-osteoarthritis.

Anaïs Lhôte - PasseportSanté.net

Source: Imithi yakho, UPhilippe moser