I-Alzheimer. Izici zobuntu ezimbili zinomthelela ekuwohlokeni komqondo. Iyini ingozi yakho?

I-Alzheimer's ibhubhisa ingqondo ngendlela engenakulungiseka, isuse inkumbulo kanye nekhono lokuphila ngokuzimela. Naphezu kokuthi amashumi ezigidi zabantu asevele enenkinga nayo (futhi inombolo ikhula ngokushesha), lesi sifo sisafihla izimfihlo. Namanje akwaziwa kahle ukuthi yini ebangela inqubo ebhubhisayo ohlelweni lwezinzwa. Nokho, ososayensi bathola enye indlela. Kuvela ukuthi izici ezimbili zobuntu zingase zivune ukuthuthukiswa kwe-Alzheimer's. Yini ngempela eyatholwa?

1. I-Alzheimer's yisifo sobuchopho esingalungiseki esicekela phansi kancane kancane inkumbulo namandla okucabanga. - Kufika ephuzwini lokuthi umuntu akakhumbuli ukuthi wenzani ngaphambili noma okwenzeka esikhathini esidlule. Kukhona ukudideka okuphelele nokungakwazi ukuzisiza - kusho udokotela wezinzwa uDkt. Milczarek
2. Ukunqwabelana kwama-amyloid plaque kanye ne-tau ebuchosheni kwaziwa ukuthi kuhlotshaniswa nesifo i-Alzheimer kanye nokuwohloka komqondo okuhlobene.
3. Ucwaningo olwenziwa ososayensi lubonise ukuthi izici ezimbili zobuntu zingahlotshaniswa nokuthuthukiswa kwe-Alzheimer's, futhi ikakhulukazi nokubekwa kwalezi zinto ebuchosheni.
4. Ulwazi olubalulekile lungatholakala ekhasini eliyisiqalo le-Onet.

Isifo I-Alzheimer's - Kwenzekani Kuwe Futhi Kungani

Isifo i-Alzheimer's yisifo esingelapheki sobuchopho esibhubhisa ama-neurons (ubuchopho buyancipha kancane kancane), kanjalo nenkumbulo, ikhono lokucabanga futhi, ekugcineni, ikhono lokwenza imisebenzi elula kakhulu. Isifo i-Alzheimer siyathuthuka, okusho ukuthi izimpawu zikhula kancane kancane eminyakeni eminingi, okuholela ezinkingeni eziningi kakhulu.

Esigabeni esithuthukisiwe, isiguli asisakwazi ukwenza imisebenzi evamile yansuku zonke - asikwazi ukugqoka, ukudla, ukugeza, ukuthembela ngokuphelele ekunakekelweni kwabanye. - Kufika ephuzwini lokuthi umuntu akakhumbuli ukuthi wenzani ngaphambili noma okwenzeka esikhathini esidlule. Kukhona ukudideka okuphelele nokungabi nakuzisiza - kusho udokotela wezinzwa uDkt. Olga Milczarek wase-SCM Clinic e-Krakow enkulumweni ye-MedTvoiLokona. (Ingxoxo Egcwele: Ku-Alzheimer's, ubuchopho buyashwabana futhi bushwabane. Kungani? kuchaza udokotela wezinzwa).

Kuyaziwa ukuthi imbangela yesifo i-Alzheimer's ukwakheka kwezinhlobo ezimbili zamaprotheni ebuchosheni: okuthiwa yi-beta-amyloid; kanye namaprotheni e-tau athatha indawo yamangqamuzana ezinzwa. - Le ndawo iba yi-granular, emanzini, i-spongy, isebenza kancane kancane futhi ekugcineni inyamalale - kuchaza uDkt Milczarek. Indawo lapho lezi zinhlanganisela zinqwabelana khona inquma izimpawu ezizovela esigulini esinikeziwe.

Ngeshwa, namanje akwaziwa kahle ukuthi yini ebangela le nqubo ebhubhisayo. Kungenzeka ukuthi kuthonywe inhlanganisela yezinto zofuzo, imvelo kanye nendlela yokuphila. Ukubaluleka kwanoma yikuphi kwalokhu ekwandiseni noma ekwehliseni amathuba okuba nesifo kungahluka kumuntu nomuntu. Kulo mkhakha, ososayensi bathole into ejabulisa kakhulu. Kuvele ukuthi izici ezimbili zobuntu z zingase zithande noma zehlise ubungozi bezinguquko ezilimazayo ebuchosheni. Imiphumela yokuhlaziya yanyatheliswa kumagazini wesayensi we-Biological Psychiatry.

Izici zobuntu ezakha i-Big Five. Asho ukuthini?

Ngaphambi kokuthi sichaze ukuthi yiziphi izici, kufanele sikhulume ngalokho okubizwa ngokuthi i-Big Five, imodeli yomuntu siqu equkethe izici ezinhlanu ezibalulekile. Ososayensi baye babhekisela kuzo.

1. Funda futhi: Amazinga kashukela ne-cholesterol kanye nengozi ye-Alzheimer's. “Abantu ababoni”

Lezi zici zaziwa ngokukhula ebuntwaneni futhi, ngokusho kochwepheshe bezempilo yengqondo, "zinethonya elibanzi emiphumeleni ebalulekile yokuphila". I-Big Five iqukethe:

Ukuvumelana - isimo sengqondo emhlabeni wezenhlalo. Lesi sici sichaza umuntu onombono omuhle kwabanye, onenhlonipho, onozwela, owethembayo, oqotho, obambisanayo, ozama ukugwema izingxabano.

Ukuvuleleka - ichaza umuntu onelukuluku lokwazi ngomhlaba, ovulekele okuhlangenwe nakho okusha / imizwa egeleza ivela ezweni langaphandle nelangaphakathi.

Ukuphakanyiswa - kubhala indoda efuna injabulo, ekhuthele, enobudlelwane kakhulu, ezimisele ukudlala

Ukucophelela - ichaza umuntu onomthwalo wemfanelo, onesibopho, ocophelelayo, ogxile ezinhlosweni futhi ogxile emininingwaneni, kodwa futhi ocophelelayo. Nakuba ukuqina okukhulu kwalesi sici kungase kuholele ngisho nasekugxileni emsebenzini, obuthakathaka kusho ukunganaki ukufeza imisebenzi yakhe nokuzenza ngokuzenzakalelayo.

Neuroticism - kusho ukuthambekela kokuba nemizwa engemihle, njengokukhathazeka, intukuthelo, ukudabuka. Abantu abanezinga eliphezulu lalesi sici bathambekele ekucindezelekeni, bahlangabezana nazo zonke izinkinga kakhulu, futhi izimo zokuphila ezivamile zingase zibonakale zisongela kakhulu futhi zibakhungathekisa. Banobunzima bokubuyela ekulinganeni kwemizwelo, futhi ngokuvamile kuthatha isikhathi eside.

Abacwaningi benze ukuhlaziya okubili okuholele esiphethweni esisodwa. Kubhekiselwa ezicini ezimbili zokugcina zeBig Five: unembeza kanye ne-neuroticism.

Izici ezimbili ze-Big Five nomthelela wazo ekuthuthukisweni kwe-Alzheimer's. Izifundo ezimbili, isiphetho esisodwa

Bangaphezu kuka-3 abantu ababambe iqhaza ocwaningweni. abantu. Okokuqala, sihlaziye idatha evela kubantu ababamba iqhaza ku-Baltimore Longitudinal Study of Aging (BLSA) - ucwaningo lwaseMelika oluthathe isikhathi eside kakhulu mayelana nokuguga komuntu.

Ukuze kutholakale izici ze-Big Five, ababambiqhaza bagcwalise uhlu lwemibuzo oluqukethe izinto ezingama-240. Kungakapheli unyaka owodwa kuqedwe lo mbhalo, ababambiqhaza bahlolelwa ukuba khona (noma ukungabikho) kwama-amyloid plaque kanye ne-tau ebuchosheni babo. Lokhu kwenziwe kwaba nokwenzeka yi-PET (positron emission tomography) – ukuhlolwa kwe-imaging okungahlanyisi.

Umsebenzi wesibili wawuwukuhlaziywa kwemeta kwezifundo eziyi-12 ezaziphenya ubudlelwano phakathi kwe-Alzheimer's pathology kanye nezici zobuntu.

I ucwaningo olusekelwe ku-BLSA kanye nokuhlaziywa kwe-meta kwaholela esiphethweni esifanayo: ukuhlangana okuqine kakhulu phakathi kwengozi yokuba nokuwohloka komqondo kwakuhlobene nezici ezimbili: i-neuroticism kanye nonembeza. Abantu abanamazinga aphezulu e-neuroticism noma unembeza ophansi babesemathubeni amaningi okuthuthukisa ama-amyloid plaque kanye nokuhlangana kwe-tau. Abantu abanamaphuzu okuqaphela okuphezulu noma amaphuzu aphansi e-neuroticism mancane amathuba okuba bakuzwe lokho.

1. Thola okuningi: Abantu abasha baphinde bahlaselwe yi-dementia kanye nesifo i-Alzheimer's. Indlela yokubona? Izimpawu ezingavamile

Umuntu angase abuze ukuthi ingabe lobu budlelwano buqala ngezinga elithile lokuqina lazo zombili izici. UDkt. Antonio Terracciano, weFlorida State University Department of Geriatrics, unempendulo: Lezi zixhumanisi zibonakala ziqondile, azinawo umkhawulo […]

Ucwaningo olushiwo ngenhla lwaluyimvelo yokubuka, ngakho aluzange lunikeze impendulo embuzweni wokuthi yiziphi izindlela ezibangela lesi simo esitholakele. Nakuba ucwaningo olwengeziwe ludingeka lapha, ososayensi banemibono eminingana.

NgokukaDkt. Claire Sexton, umqondisi wezinhlelo zocwaningo nosizo ku-Alzheimer's Association (engahileleki ocwaningweni), “indlela eyodwa engase ibe khona ukuvuvukala okuhlobene nobuntu kanye nokuthuthukiswa kwezimpawu ze-Alzheimer's biomarker. "Indlela yokuphila ingenye indlela engaba khona," kuphawula uDkt. Sexton. - Isibonelo, abantu abanonembeza ophezulu baye baboniswa ukuthi baphila impilo enempilo (ngokuphathelene nokusebenza ngokomzimba, ukubhema, ukulala, ukukhuthazwa kwengqondo, njll.) kunalabo abanonembeza ophansi.

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