Okuqukethwe
Hhayi kuphela izinkinga zenkumbulo. Izimpawu zokuqala zesifo i-Alzheimer zingase zivele ngaphambi kwesikhathi. “Imiphumela yesamukeli ebuchosheni ehlobene nesisusa nemizwelo iholela ekufeni kwezinzwa nokuphazamiseka kwesakhiwo se-synaptic kubantu abanesifo i-Alzheimer,” kubika ososayensi base-Indiana University School of Medicine kumagazini i-Molecular Psychiatry.
- Nakuba isifo i-Alzheimer sihlotshaniswa nabantu asebekhulile, ososayensi abaningi ngokwengeziwe baveza ukuthi izimpawu zaso zakuqala zingavela cishe eminyakeni engamashumi amane.
- Manje sekutholakele ukuthi kudala ngaphambi kwezinkinga zenkumbulo, iziguli ziba nezimpawu ezinjengokunganaki nokucasuka.
- Ulwazi olwengeziwe lungatholakala ekhasini eliyisiqalo le-Onet
Isifo I-Alzheimer's - Yiziphi Izindawo Zobuchopho Esizithintayo?
Ocwaningweni lwabo, ososayensi bagxile ku-nucleus accumbens (enye ye-basal ganglia) etholakala ku-striatum. Le ndawo iyingxenye yohlelo lokuklomelisa futhi ithinta ugqozi.
– Kube nentshisekelo encane ku-nucleus accumbens njengesakhiwo esihlobene nesifo i-Alzheimer's. Ikakhulukazi icwaningwa ukuze iqonde izinqubo ezikhuthazayo nezingokomzwelo. Ucwaningo lwangaphambilini, nokho, luthole ukuthi umthamo we-nucleus accumbens, kanye nezifunda ze-cortical kanye ne-hippocampus, uyancipha ezigulini ze-Alzheimer, ababhali bayaphawula.
Ngisho nangaphambi kokuba ukwehla komqondo kubonakale, abantu abaningi abanesifo i-Alzheimer's bahlangabezana nokushintshashintsha kwemizwelo, futhi ngokuvamile babe nezimpawu zokucindezeleka.
Ingabe uyafuna ukwazi imbangela yokugula kwakho? Yenza Ukuguquka Kwemizwa - iphakethe lokuhlola elihlola izimbangela zokugula okutholakala enguqulweni enesampula yegazi lasekhaya, okuzokwenza kube lula ukuxilonga, ikakhulukazi kubantu asebekhulile abanobunzima bokufinyelela esikhungweni sezokwelapha.
Ukunganaki nokucasuka - izimpawu zokuqala ze-Alzheimer's?
- Kodwa-ke, izimpawu ze-neuropsychiatric, njengokunganaki nokucasuka, zenzeka ngaphambi kwezinkinga zenkumbulo, ngakho-ke kunzima ukuphendula ngesikhathi.. Ngakho-ke, kudingeka siqonde ukuthi kungani lezi zimpawu zivela nokuthi zihlobene kanjani nokushoda kwengqondo, kugcizelela umbhali wocwaningo, uDkt. Yao-Ying Ma.
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Ngokutadisha imodeli yesifo i-Alzheimer's, ososayensi bahlonze ama-CP-AMPA (calcium ion permeable) receptors kuma-nucleus accumbens abandakanyeka ekudluliselweni okusheshayo kwe-synaptic. Lawa ma-receptors, ngokuvamile angekho kule ngxenye yobuchopho, avumela ama-ion e-calcium ukuthi angene kumangqamuzana ezinzwa. I-calcium eningi, nayo, iholela ekuphazamisekeni kwemisebenzi ye-synaptic futhi ibangele izinguquko eziningi ze-intracellular ezingabangela ukufa kwe-neuronal.
Lokhu kulahlekelwa kokuxhumana kwe-synaptic kubangela izinkinga zokugqugquzela. Ngakho-ke, ukukhomba nokuvimbela ama-CP-AMPA receptors kungabambezela ukukhula kwesifo i-Alzheimer's.
- Uma sikwazi ukulibazisa izinguquko ze-pathological kwenye yezindawo ezithintekile, isibonelo ku-nucleus accumbens, kungase kube nomthelela ekubambezelekeni kwezilonda nakwezinye izindawo - kuphawula uDkt Ma.
Ingabe udinga iseluleko esikhethekile esivela kudokotela wezinzwa? Ngokusebenzisa umtholampilo we-haloDoctor telemedicine, ungakwazi ukubonana nezinkinga zakho zemizwa nochwepheshe ngokushesha futhi ngaphandle kokushiya ikhaya lakho.