Ebizwa nangokuthi “izidakamizwa zomgunyathi”, ama-placebo anomphumela we phatha ngaphandle, nokho, equkethe noma yimuphi umgomo osebenzayo ovumela ukuphulukiswa. Isiraphu kashukela, i-capsule kafulawa, njll., izimo zabo nezethulo zihlukahlukene kodwa zonke zinomphumela ofanayo womlingo: benza kusebenze ebuchosheni ukukhiqizwa kwama-endorphin, amahomoni enjabulo nokukhululeka. 

Ukuthatha isibulali-zinhlungu futhi uzizwe ungcono uma usugwinywe, wazi ukuthi kuthatha cishe ihora elingu-½ ukuze umzimba uwuhlanganise futhi ngaleyo ndlela uwenze usebenze, yilokho okubizwa ngokuthi umphumela we-placebo. .