Isifo sikaPaget singathinta ithambo elilodwa noma ngaphezulu. Kuthinta kuphela amathambo aqale athinteka (akukho kwandiso okungenzeka kwamanye amathambo).

Imvamisa i-asymptomatic, itholwe ngenhlanhla ngesikhathi sokuhlolwa kwe-radiographic okwenziwa ngesinye isizathu.

Izimpawu zomtholampilo eziningana zingadalula lesi sifo futhi zithethelele ukunikezwa kokuhlolwa kwe-radiological:

-ubuhlungu bamathambo

-ukukhubazeka kwamathambo : azishintshi futhi sekwephuzile (uphawu lwesigqoko nge-hypertrophy [ukwenyuka kwevolumu] yogebhezi, i-saber-blade tibia, ukucaba kwethorax, ukuwohloka komgogodla [kyphosis])

-iphazamisa ama-vasomoteurs (okungajwayelekile kwemithambo yegazi) okubangela i-hyperemia (ukugeleza kwegazi ngokweqile okubangela ububomvu) esikhumbeni eduze kwezilonda zamathambo

Qaphela ukuthi akukho ukuwohloka kwesimo esijwayelekile.

Amathambo athinteka kakhulu yilesi sifo amathambo e-pelvis, i-dorsal ne-lumbar vertebrae, i-sacrum, i-femur, i-skull, i-tibia.

The ama-x-ray yenza kube nokwenzeka ukugqamisa izimpawu zesifo:

- ukungahambi kahle komumo: i-bone hypertrophy (ukwenyuka kwevolumu)

- ukungahambi kahle kwesakhiwo: ukuqina kwama-corticals (izindonga zamathambo)

-i-density anomalies: ukufiphala okuhlukahlukene kwethambo okunikeza ukubukeka okuphekiwe

I-Bone scintigraphy ingagqamisa i-hyperfixation ejulile emathanjeni athintekile. Isithakazelo esiyinhloko salokhu kuhlolwa ukuhlonza amathambo athintwe yilesi sifo. Nokho, asikho isidingo sokuphinda ngesikhathi sokuqapha nokwelashwa kwesiguli.

Ukwanda kwe-alkaline phosphates egazini kuhambisana nezinga kanye nomsebenzi wesifo. Ibonisa umsebenzi oqinile wokwakheka kwamathambo. Lesi silinganiso singase sibe esivamile uma lesi sifo sitholakala ethanjeni elilodwa.

Imithamo ye-crosslaps (ebuye ibizwe ngokuthi i-CTx noma i-NTx) nama-pyridinolines egazini noma emchameni iyakhuphuka futhi ifakazele umsebenzi wokubhujiswa kwamathambo.

Ngokungafani ne-bone scan, lezi zikena ziwusizo ekuhloleni isifo esingaphansi kokwelashwa. Kanjalo, zenziwa njalo ezinyangeni ezi-3 kuye kweziyisi-6.

Ukuqaphela ukuthi:

-calcemia (izinga le-calcium egazini) ngokuvamile livamile. Ingandiswa uma kwenzeka i-immobilization isikhathi eside noma i-hyperparathyroidism ehambisanayo.

-Izinga le-sedimentation nalo lijwayelekile.

The izinkinga Izimpawu zesifo ziyahlukahluka ukusuka kwesinye isiguli kuye kwesinye futhi zilandelana kanje:

-khuluma : ikakhulukazi ezithinta i-hip nedolo, zixhunyaniswa nokukhubazeka kokuphela kwamathambo okubangelwa isifo futhi banesibopho sobuhlungu, ukuguqulwa nokungasebenzi kahle.

-amathambo : ukuphuka kubangelwa amathambo abuthakathaka

Akuvamile, izinkinga zingavela:

-inzwa : okuhlobene nokucindezelwa kwezinzwa ngokuguqulwa kwamathambo. Ngakho-ke, kungenzeka ukubona ubuthulu ezikhathini eziningi (okuthinta zombili izindlebe), i-paraplegia (engelashwa)

-inhliziyo : ukuhluleka kwenhliziyo

Ngokukhethekile, ukuvela kwesimila esiyingozi singenzeka ethanjeni elihlaselwe yilesi sifo (i-humerus ne-femur). Ukwanda kobuhlungu nokungajwayelekile kwe-radiographic kungase kuphakamise lokhu kuxilongwa, okungaqinisekiswa kuphela ngokuqiniseka ngokwenza i-biopsy.

Isifo sikaPaget akufanele sidideke:

- i-hyperparathyroidism

-ama-bone metastases kusuka kumdlavuza webele noma umdlavuza wendlala yesinye

i-myeloma eminingi (ebizwa nangokuthi isifo sika-Kahler)