Ezigulini ezingu-80%, lesi sifo siqala ukubonakala njengobuthakathaka bemisipha ezinyaweni (= unyawo lwehla) kanye nezandla, kulandelwa i-atrophy nokukhubazeka. Ubuthakathaka buhambisana namajaqamba emisipha kanye nama-spasms, ngokuvamile ezingalweni nasemahlombe. Kungase futhi kube nokundindizela.

Ngemuva konyaka owodwa noma emibili yokuziphendukela kwemvelo, ukuphazamiseka kokubandakanyeka kwe-bulbar (okuchazwe ngezansi) kuvela.

Ezigulini ezingamaphesenti angu-20, lesi sifo siqala ukubonisa izimpawu zokulimala kwe-medulla oblongata, okuwukuthi kunzima ukukhuluma (= ubunzima bokukhuluma, izwi elibuthakathaka, elingenalutho), okubizwa ngokuthi i-dysarthria kanye nobunzima bokuhlafuna nokugwinya (dysphagia). Kamuva, iziguli zikhona ezinobuthakathaka bemisipha yemilenze nesiqu esizichaze ngenhla:

• Ukuncipha kokuxhumana kanye nobuciko
• Ukukhathala okuphawulekayo
• ukuqothuka
• ukuqunjelwa
• Ubuhlungu, ikakhulukazi ubuhlungu bemisipha
• I-Sialorrhée (hypersalivation)
• Izinkinga zokulala
• Ubunzima bokuphefumula, ngenxa yokukhubazeka okuqhubekayo kwemisipha yokuphefumula ku-thorax. Lo monakalo uvela kamuva phakathi nenkathi yesifo
• Ukonakala kwemisebenzi yokucabanga okubonakala ku-30 ​​kuya ku-50% weziguli, ngokuvamile izinguquko ezincane ebuntwini, ukucasuka, ukuthatheka, ukunciphisa ukuzigxeka kanye nezinkinga zokuhlela nokwenza imisebenzi. Ezimweni ezingaba ngu-15%, kukhona ukuwohloka komqondo we-frontotemporal, nokungahleleki okuphawulekayo kanye nokuvinjelwa.

Abantu abasengozini

Abesilisa bathinteka kancane kunabesifazane.

Izici zengozi

Kunezinhlobo zofuzo zesifo sikaCharcot (cishe i-10% yamacala). Iminyaka yobudala nayo iyisici esiyingozi.