Ososayensi baseLodz University of Technology basungule indlela entsha yokugqokisa i-hydrogel yokwelapha amanxeba anesifo sikashukela. Ukugqoka kuletha i-tetrapeptide esilondeni esingabuyisela futhi senze imithambo yegazi emisha ngaphakathi kwalo.
Ngokusho kwabacwaningi, ukusetshenziswa kwalolu hlobo lokugqoka kunganciphisa isibalo sokunqunywa kwezitho.
Ukwelashwa kwezilonda ezinesifo sikashukela njengamanje kuyinkinga enkulu ePoland nasemhlabeni kunokwelashwa kwezinye izinhlobo zamanxeba. Izindleko zalezo zindlela zokwelapha kanye nemiphumela yezenhlalo yamanxeba esifo sikashukela zinkulu - ngenxa yalesi sizathu ePoland ukwelashwa okungaphezu kwe-10 kwenziwa ngonyaka. ukunqunywa isitho. Ngenxa yokucaciswa kwala manxeba, awekho ama-biomaterials athuthukisiwe emhlabeni angakhulisa kakhulu amathuba okuphola kwawo.
Ithimba lika-prof. U-Janusz Rosiak ovela ku-Interdepartmental Institute of Radiation Technology yase-Lodz University of Technology usethuthukise ubuchwepheshe bokukhiqizwa kwezingubo ze-hydrogel ezinothiswe nge-tetrapeptide, ebangela i-angiogenesis, okungukuthi ukubuyisela nokudala imithambo yegazi emisha ngaphakathi kwenxeba. Ukuhlolwa kweselula kwalezi zinto eziphilayo kunikeza imiphumela emihle.
Ukugqoka kwakhiwe ngesisekelo se-hydrogel yokugqoka eyakhiwe ososayensi base-Łódź, okuyinto - ngokobuchwepheshe babo - ekhiqizwa emhlabeni wonke iminyaka engaphezu kwengu-20. Inezimfanelo zokugqoka kahle, futhi ngenxa yayo, imiphumela emihle kakhulu itholakala ekwelapheni izilonda zokusha, izilonda zokulala kanye namanxeba okunzima ukuwapholisa, isb izilonda ze-trophic.
I-Hydrogel dressing isetshenziswa ngqo enxebeni, kuhl. inikeza ukufinyelela komoyampilo esilondeni, kwakha isithiyo ngokumelene nokutheleleka kwangaphandle, kudonsa ama-exudates, kuhlinzeka indawo emanzi, kukhulula ubuhlungu, kususe izicubu ze-necrotic enxebeni lapho zikhishwa enxebeni. Ngesikhathi esifanayo, kwenza kube nokwenzeka ukulinganisa into yomuthi (kulokhu i-tetrapeptide) ngokuqhubekayo, isilinganiso esinqunyiwe, ngaphandle kwesidingo sokungenelela kukadokotela.
Kubonakala sengathi ikhambi esilikhiqizile lingaba usizo kakhulu ekwelapheni amanxeba anesifo sikashukela. Izindleko zokukhiqiza ziphansi kakhulu, futhi ukukhiqizwa kwayo kungenziwa ngaphandle kokutshala izimali ezinkulu - etshela i-PAP, umdali wezingubo zokugqoka, uProf. Janusz Rosiak.
Ukugqokwa kokwelashwa kwezilonda ezinesifo sikashukela njengamanje kudinga ukuthi kuqalwe ukuhlolwa kwangaphambi komtholampilo kanye nokwelashwa, okuthi - njengoProf. Rosiak - akuxhaswe nguhulumeni. Yingakho sizimisele ukubambisana nezinkampani ezinentshisekelo ekukhiqizweni kwezingubo ezinjalo - wanezela.
Ngesikhathi sokwelashwa nge-classic hydrogel dressing ekhiqizwa ngokwendlela kaRosiak, kwatholakala ukuthi inomphumela onenzuzo futhi ekwelapheni okuthiwa unyawo lwesifo sikashukela, kodwa amathuba okuphulukisa lolu hlobo lwesilonda ngokusetshenziswa kokugqoka okunjalo. cishe amaphesenti angu-50. - kakhulu njengezinye izinhlobo zokugqoka ezaziwa futhi ezisetshenziswa emhlabeni.
Lokhu kuhlobene nokucaciswa kwezilonda zesifo sikashukela, njengoba zihlukaniswa, phakathi kokunye, i-necrosis yezicubu zamanxeba ngenxa yokulimala nokubhujiswa kwemithambo yegazi. Kubuye kuhlotshaniswe nokucekelwa phansi kwezicubu zezinzwa kanye nokufa kancane kancane kwezicubu ezizungeze isilonda.
Imizamo yokwelapha lolu hlobo lwamanxeba, eyenziwa ePoland nasemhlabeni wonke, yehlela ekuboneni uhlobo lwezifo ezibangelwa amagciwane nokusebenzisa ama-antibiotics noma ezinye izinto ezisebenzayo ezingathuthukisa ukuhlanzeka kwesilonda. Ngesikhathi silinde ukuthi isilonda siphole, izici ezingabangela i-angiogenesis, okungukuthi ukubuyiselwa kanye nokwakheka kwemithambo yegazi emisha ngaphakathi kwesilonda, zingalethwa kuso. Ngale njongo, ukusetshenziswa kwenani lezinto, okuthiwa yizici zokukhula.
UProf. Rosiak wachaza ukuthi ocwaningweni lwabo, ososayensi base-Łódź bahlangabezane nemibiko ezincwadini mayelana nokusetshenziswa kwe-tetrapeptide elula ukuze kutholwe i-angiogenesis ngokuyiletha endaweni ephathwayo yomzimba. Kuyinhlanganisela edalwe ngokwemvelo emzimbeni womuntu, enesigamu sempilo emfushane uma kuqhathaniswa nemizuzu emi-5, yingakho ukugxila kwayo entweni esebenza ngokujwayelekile kuphansi kakhulu. Le tetrapeptide ibhaliswe njengomuthi futhi yavunyelwa yi-US Food and Drug Administration (FDA).
Kodwa-ke, ukuphathwa kwayo ezicutshini ezizungeze isilonda kwenziwa ngomjovo, okwenza kube nzima ukulawula indawo yesenzo futhi kubangele imiphumela evamile - ukufinyelela ngokushesha ekugxilweni okuphezulu kanye nokunyamalala okusheshayo okulinganayo, okubhubhisa umphumela wayo wokwelapha. Umbono wethu wokuqala, emhlabeni wonke, ufinyelela ekuzameni ukuhlanganisa i-hydrogel yokugqoka nale tetrapeptide - kuchaza usosayensi.
Ubuchwepheshe bokukhiqiza ukugqoka kwe-hydrogel okuthuthukiswe abacwaningi be-Łódź kuhlanganisa ukudala ingxube yezithako zokugqoka emanzini (amanzi abala ngaphezu kwe-90% yokwakheka kwawo), bese kuthi ngemva kokuyibeka ephaketheni futhi ayivale, ayifake inzalo insimbi ye-electron. Ngenxa yalokho, kwakheka isiqephu se-hydrogel esiyinyumba esisetshenziswa njengokugqoka.
Inkinga yocwaningo yayiwukuthi ingabe into esebenzayo ngeke ibhujiswe ngesikhathi sokuvala inzalo, ngoba i-tetrapeptide esixazululweni samanzi ngaphansi kwethonya le-electron beam ibhujiswa ngokuphelele kakade kumithamo yama-electron angakaqinisekisi ubunyumba bomkhiqizo. Nokho, sikwazile ukuxazulula le nkinga - wanezela u-prof. Rosiak.
Isixazululo sithunyelwe ukuze sivikelwe eHhovisi Lelungelo Lobunikazi. Ngenxa yokusekelwa kwezezimali kweNational Center for Research and Development, ososayensi baseLodz benza ucwaningo mayelana ne-kinetics yokukhululwa kwe-tetrapeptide esilondeni, ukuqina kwayo ekugqokeni (ingasetshenziswa ngisho nonyaka owodwa ngemva kokukhiqizwa kwayo) kanye ukusebenzisana namaseli.
Ezingeni lamangqamuzana, siqinisekisile ukubonakaliswa kwezakhi zofuzo ezibhekene ne-angiogenesis, futhi ezingeni lamaselula, ukusheshisa okuphawulekayo kokwanda kwamaseli e-endothelial. Siphinde sabonisa ukuncika kwemiphumela etholiwe ekugxilweni kwe-tetrapeptide futhi sanquma umthamo ophelele - uprofesa waphawula.
Ososayensi bamemezela ukuthi uma bengawutholi umthombo wokuxhasa ucwaningo olwengeziwe mayelana nokugqokwa, abakhiphi ukuthi bazoveza ulwazi lombono wabo esidlangalaleni. Inkinga yokwelapha okuthiwa unyawo olunesifo sikashukela ithinta abantu emhlabeni wonke futhi akudingekile ukuthi senze imali ngayo - ukholelwa ukuthi u-prof. Rosiak. (PAP)