I-Macrophage myofasciitis ibonakala ngezilonda ze-histopathological (isifo esithinta izicubu). Lena imiphumela ye-myopathological, okusho ukuthi umthelela wezicubu zemisipha.

Lesi sifo sichazwe ngokulandela i-biopsy yomuntu, evela esigulini esikhulile nasezinganeni ezi-3. Ukulimala ngaphakathi kwemicu yemisipha kuye kwagqanyiswa ngaphandle kokuba khona kwe-necrosis. Ukuhlolwa kwalezi zilonda (i-nuclear microprobes, i-radiographic microanalyses, i-atomic absorption spectrometry) yenza kube nokwenzeka ukuqonda ukuthi lo monakalo wakhiwe usawoti we-aluminium. Lezi zinto zisetshenziswa kakhulu enanini elikhulu lemithi yokugoma elawulwa nge-intramuscularly. Kuphinde kwavela ukuthi asikho isizathu esidala lesi sifo. Ngempela, abantu abanempilo (abangaguli, abaphila ngendlela enempilo, njll.) bangathinteka yilesi sifo ngemva kokugonywa. (1)

Ekuqaleni, umsuka walesi sifo wawungaziwa. Izinsolo mayelana nemvelo, izifo ezithathelwanayo kanye nezinye seziphakanyiswe. Umsebenzi wesayensi owenziwa phakathi kuka-1998 no-2001 wanquma ukuthi imbangela yangempela yalesi sifo ukumuncwa kwe-aluminium hydroxide ekhona emithini yokugoma. Ukuhlolwa kwe-imaging ye-Microscopic yezingxenye zangaphakathi: ama-macrophages abonise ukuba khona okuqhubekayo kokuhlanganisa okubangelwa lawa ma-salt aluminium. Lezi zinhlanganisela zisetshenziswa njengama-adjuvants emithini yokugoma. I-Macrophage myofasciitis itholakala kuphela ku-deltoid kubantu abadala naku-quadriceps ezinganeni.

Izimpawu eziyinhloko ezihambisana nalesi sifo yilezi:

- ubuhlungu obungapheli emisipha: ukukhula kancane kancane (isikhathi sezinyanga ezimbalwa). Lezi zimpawu zithinta phakathi kuka-55 kuya ku-96% weziguli ezihlaselwe yilesi sifo. Kuye kwaboniswa ukuthi lezi zibonakaliso zomtholampilo ngokuvamile zikhula kude nezimbambo ezincane futhi kancane kancane zisakazeka kuwo wonke umzimba. Ngeziguli ezimbalwa, lobu buhlungu bemisipha buholela ezinkingeni zokusebenza. Ukwengeza, ubuhlungu bomgogodla buvame ukubonakala. Lezi zinhlungu zivame ukuzwakala ngokushesha lapho umuntu evuka futhi agcizelelwe phakathi nokuzivocavoca umzimba kanye nemisebenzi yansuku zonke;

- ukukhathala okungamahlalakhona, okuthinta phakathi kuka-36 no-100% weziguli. Lokhu kukhathala okukhulu ngokuvamile kubangela ukuncipha kwemisebenzi yomuntu yansuku zonke, kokubili ngokwengqondo nangokomzimba;

- ukuphazamiseka kwengqondo, imiphumela enganakwa isikhathi eside kulesi sifo. Lokhu kubonakaliswa kubangela ukucindezeleka, ukwehla kokusebenza kwengqondo nokuhlakanipha, ukuphazamiseka kokunaka, njll.

Ezinye izimpawu zesici nazo zingahlotshaniswa nesifo. Lokhu kuhlanganisa ukubonakaliswa kwengqondo, ikakhulukazi ukuphazamiseka kwemizwelo.

I-Dyspnea (ukuphefumula kanzima) kanye nekhanda elibuhlungu kuye kwabikwa kwezinye iziguli.

Umsuka walesi sifo ukuba khona kwe-aluminium hydroxides emithini yokugoma ejovwa ezigulini ngomzila we-intramuscular.

I-Macrophage myofasciitis ithinta kokubili amadoda nabesifazane, abantu abadala kanye nezingane, ngaphandle kwesimo esithile esiyisisekelo, kulandela ukugonywa. Ngokuvamile abantu abadala bayathinteka ngemva kokugoma ku-deltoid, kuyilapho izingane ziyathinteka ngemva kokujova ku-quadriceps.

Imithi yokugoma ethinteka kakhulu ngokuba khona kukasawoti we-aluminium njenge-adjuvant yile:

1. umuthi wokugomela i-hepatitis B: 84%;

2. umuthi wokugomela i-tetanus: 58%;

3. umgomo wokulwa ne-hepatitis A: 19%.

Ngaphezu kwalokho, kuye kwaboniswa ukuthi ukuba khona kosawoti we-aluminium emzimbeni kuyaphikelela. Noma ukuthi ukugcwaliseka kwe-biopsy yezicubu zemisipha kungafakazela ukuba khona kwalezi zinhlanganisela umsuka wazo uwumuthi wokugoma osukela eminyakeni embalwa edlule. (3)

Kungase futhi kubonakale sengathi kukhona i-predispositions kwabanye abantu, ingabavumeli ukuthi baqede kahle usawoti we-aluminium otholakala emithini yokugoma futhi ngalo mqondo, babone benqwabelana ezicubu zemisipha.

Izingozi zomuntu ngamunye zokuthuthukiswa kwesifo azizange ziboniswe ngokucacile.

Ukuxhumana phakathi kwezimpawu zesistimu nokuthuthukiswa kwezifo kuye kwaboniswa engxenyeni encane yamacala e-macrophage myofasciitis.

Ngaphezu kwalokho, kuye kwasolwa izakhi zofuzo, ikakhulukazi ezimweni eziphindaphindiwe zesifo phakathi kwezelamani ezifanayo. Olunye ucwaningo lwesayensi lubonise ukuthi ifa elithile lofuzo lingaba nomthelela ekuphikeleni kosawoti we-aluminium ezicutshini zemisipha. I-pathology ibonakala ngokwanda kokujikeleza kwe-CCL2 / MCP-1, i-cytokine ehilelekile ekungeneni kwama-nanoparticles ebuchosheni. Izinguquko zofuzo kuzakhi zofuzo ezifaka le molekyuli zingaba enye into engozini yokuthuthukisa lesi sifo.

Ukuxilongwa kwesifo kwenziwa ngokuya ngezimpawu zomtholampilo ezahlukahlukene ezibonakala kancane. Impela, eyokuqala ihlobene nokuba khona kukasawoti we-aluminium, kusukela kumjovo wokugoma, ezicutshini zemisipha.

Ngaphezu kwalokho, ukutholakala kwe-myalgia (ubuhlungu bemisipha) ku-deltoid ehambisana nokuhlonza i-aluminium hydroxides ngaphakathi kwalesi zicubu, kanye nobufakazi bokuthuthukiswa kwe-pathology kubantu abadala.

Ukunqunywa kokubonakaliswa komtholampilo (ubuhlungu bemisipha obungapheli, ukukhathala okungapheli kanye nokungaqondakali kwengqondo) kwenza kube nokwenzeka ukusungula noma cha ukutholakala kwesifo.

Ukuxilongwa okuhle kwalesi sifo kuhilela ukutholakala kwezilonda kuma-macrophages e-deltoid kubantu abadala kanye ne-quadriceps ezinganeni.

Ku-1/3 yamacala, ukwanda kwezinga le-plasma creatine kinase kuyisici se-pathology. Kodwa-ke, leli zinga le-cytokine eliphakeme ngokungavamile lingase lihlotshaniswe nezinye izifo ezivuthayo noma zokuzivikela komzimba. Ngalo mqondo, izivivinyo ezengeziwe zokuqeda noma yikuphi ukusola kwesinye isizathu kufanele kwenziwe.

I-electrodiagnosis, i-MRI (I-Magnetic Resonance Imaging) yemisipha ngokuvamile yenza kube nokwenzeka ukuvuma noma ukungavumeli imibono yokuqala.