I-LDH iqoka isigaba sama-enzyme, i-Lactase dehydrogenases. Atholakala yonke indawo emzimbeni, kungakhathaliseki ukuthi kusemisipha (ngisho nasenhliziyweni), ezicutshini zamaphaphu noma kumangqamuzana egazi. I-enzyme iphrotheni indima yayo iwukugqugquzela ukusabela emzimbeni, ngamanye amazwi ukukucupha noma ukusheshisa inqubo evame ukuhamba kancane kakhulu.

Kunezinhlobo eziningana, noma ama-isoenzymes, aphawulwe ngenombolo ngokuya ngendawo yawo. Ngakho lezo zenhliziyo noma zobuchopho zithola isimo se-LDH 1 no-2, kuyilapho lawo ama-platelet nama-lymph node kuyi-LDH3, lawo esibindi i-LDH 4 nalawo esikhumba i-LDH5.

Indima ye-LDH ngaphakathi komzimba iwukugqugquzela ukuguqulwa kwe-pyruvate ibe i-lactate, futhi ngokuphambene nalokho. Lawa ma-asidi amabili anendima yokudlulisa amandla phakathi kwamaseli.

Qaphela ukuthi ibizwa nangokuthi i-lactate dehydrogenase, noma i-lactic dehydrogenase, futhi ngezinye izikhathi ifanekiselwa yi-LD.

Intshisekelo yezokwelapha yama-enzyme e-LDH ingaphezu kwakho konke ukuthola ukwanda okungavamile ebukhoneni bawo. Imvamisa, i-LDH igcinwa ngaphakathi kwamaseli omzimba. Kodwa uma izicubu zonakalisiwe, zizochitheka, futhi ngenxa yalokho zenze i-pyruvate eyengeziwe ibe yi-lactate.

Ukuzikhomba ezindaweni ezithile noma ukuqapha ukuziphatha kwazo emzimbeni ngaleyo ndlela kungenza kube nokwenzeka ukunquma indawo eye yalimala amangqamuzana, noma ukuhlola ubukhulu bayo. Kuwusizo futhi ekuboneni uhla lwezifo, kusukela ku-anemia kuya kumdlavuza (bona "Ukuhunyushwa komphumela we-LDH").

Ukuhlolwa komthamo we-LDH kwenziwa ngesampula yegazi elula. Ngokuqondile, amalabhorethri azohlaziya i-serum, uketshezi lapho izakhi zegazi ezifana namaseli abomvu egazi zigeza khona. Nakuba laba bakamuva nabo banama-enzyme e-LDH ezinhliziyweni zabo, kungaphezu kwawo wonke umthamo we-serum obalulekile ekunqumeni ukuthi izinga alijwayelekile noma cha.

Inani lereferensi lokuhlolwa kwe-enzyme ye-LDH lilinganiselwa ku-120 kuye ku-246 U / L (amayunithi ngelitha).

Ukulandelela ukuhlolwa, udokotela angakwazi ukuhlaziya imiphumela enikezwe ilabhorethri, futhi ngokunokwenzeka abone ukuphazamiseka okuhlukahlukene esigulini. Ngokuvamile, kuyodingeka ukuhlobanisa lo mphumela nezinga lamanye ama-enzyme noma ama-asidi, ngoba ukwanda okulula noma ukuncipha kwe-LDH kungaba nemvelaphi ehlukahlukene. Ngakho-ke kukhona amathuba ahlukene okuhumusha.

Uma izinga le-LDH liphezulu:

• I-anemia

Imvamisa ingaba yingozi (ebuye ibizwe ngesifo sika-Biermer), noma i-hemolytic anemia. Ekugcineni, ama-autoantibodies anamathela kumaseli abomvu egazi futhi awabhubhise, okwandisa izinga le-LDH egazini.

• I-Cancers: Izinhlobo ezithile zomdlavuza ezifana ne-neoplasias nazo zihlotshaniswa nokukhuphuka okusheshayo kwe-LDH.
• I-Infarction: Ngemva kwe-myocardial infarction, ehambisana nokulimala kwezicubu zenhliziyo, ukwanda kwamazinga e-LDH kubonakala kungakapheli amahora angu-10. Izinga libe sehla futhi emasontweni amabili alandelayo.
• I-AVC (incazelo efanayo ne-infactus)
• Pancreatitis
• Izinso kanye nezifo zamathumbu
• I-Mononucleosis
• Embolism yamaphaphu
• I-Angina pectoris
• I-dystrophy yemisipha
• I-Hepatitis (enobuthi noma evimbelayo)
• I-Myopathy (kuya ngendawo yesifo)

Uma izinga le-LDH liphansi noma livamile:

Kulokhu ukuthi akukho nkinga ekhona, noma ekhonjwa ngale ndlela, emzimbeni.

Ungakhathazeki: Nakuba lolu hlu lwezifo lungase lwesabe labo abaye baba nomphumela ophezulu we-LDH, kuhle ukukhumbula ukuthi ezinye izinto ezivamile, njengokuzivocavoca kanzima, zingabangela ukunyuka kwesikhashana kwe-LDH. egazini.

Ngakolunye uhlangothi, i-hemolysis (ukuqhekeka kwamangqamuzana egazi abomvu egazini) ngesikhathi sokuhlolwa kungabangela umphumela ongalungile. I-LDH ekhona kumaseli abomvu egazi izosabalala ngempela, futhi ngenxa yalokho ihlanekezele umphumela.

Ngemva kokuhlolwa kwezinga le-LDH, imiphumela izothunyelwa kudokotela wakho ongaxoxa ngayo futhi nawe uma kunesidingo. Uma imiphumela ikhombisa ukuba khona kokuphazamiseka, uzovele udluliselwe kuchwepheshe okukhulunywa ngaye.

Uma kwenzeka kunomdlavuza, ukuqapha njalo izinga le-LDH kungase kube uphawu lokuthi umdlavuza uphumelele noma cha, ukuze kwaziwe ukuthi amangqamuzana okuhlosiwe abhujiswa ngempela noma ahlasela ezinye izingxenye zomzimba.