Ukuxilongwa kwe-acromegaly kulula (kodwa kuphela uma ucabanga ngakho), ngoba kuhilela ukuhlolwa kwegazi ukuze kutholakale izinga le-GH ne-IGF-1. Ku-acromegaly, kunezinga eliphezulu le-IGF-1 ne-GH, ukwazi ukuthi ukugcinwa kwe-GH kuvame ukuhluka, kodwa ukuthi ku-acromegaly kuhlale kuphezulu ngoba akusalawulwa. Ukuxilongwa okuqondile kwaselabhorethri kusekelwe ekuhlolweni kweglucose. Njengoba i-glucose ivamise ukwehlisa ukukhishwa kwe-GH, ukuphathwa ngomlomo kweglucose kwenza kube nokwenzeka ukubona, ngokuhlolwa kwegazi okulandelanayo, ukuthi, ku-acromegaly, ukugcinwa kwehomoni yokukhula kuhlala kuphezulu.

Uma i-hypersecretion ye-GH iqinisekisiwe, kuyadingeka ukuthola umsuka wayo. Namuhla, izinga legolide yi-MRI yobuchopho engabonisa isimila se-pituitary gland. Ezimweni ezingavamile kakhulu, ithumba elitholakala kwenye indawo (imvamisa ebuchosheni, emaphashini noma kumanyikwe) elikhipha elinye ihomoni elisebenza ku-pituitary gland, GHRH, elikhuthaza ukukhiqizwa kwe-GH. Ukuhlola okubanzi kuyaye kwenziwa ukuze kutholwe umsuka walokhu kuphuma okungavamile.