Le i-cortisol is a i-hormone ye-steroid kukhiqizwe kusuka cholesterol futhi kukhishwa yizindlala ngaphezulu kwezinso (the i-adrenal cortex). Uketshezi lwayo luthembele kwenye i-hormone, i-ACTH ekhiqizwa yi-pituitary gland ebuchosheni (ACTH ye-adrenocorticotropin).

ICortisol idlala izindima eziningana emzimbeni, kufaka phakathi:

• Umzimba we-carbohydrate, lipids kanye namaprotheni: usiza ukulawula ushukela wegazi ngokwandisa i-glucose synthesis ngesibindi (i-gluconeogenesis), kepha futhi kukhuthaza ukukhishwa kwama-lipids namaprotheni ezicubu eziningi

• Inokusabela okulwa nokuvuvukala

• Ukulawula umfutho wegazi

• Ukukhula kwamathambo

• Impendulo yengcindezi: I-Cortisol ivame ukubizwa nge-hormone yokucindezeleka. Indima yawo ukusiza umzimba ukuthi ubhekane nakho, ngokuhlanganisa amandla adingekayo ukondla imisipha, ubuchopho kepha nenhliziyo.

Qaphela ukuthi izinga le-cortisol liyahlukahluka kuye ngesikhathi sasemini nobusuku: liphezulu kakhulu ekuseni futhi lehla usuku lonke ukufinyelela ezingeni eliphansi kakhulu kusihlwa.

Udokotela uyala ukuthi kuhlolwe izinga le-cortisol egazini ukubheka ukonakala kwezindlala ze-adrenal noma i-pituitary gland. ICortisol ne-ACTH kuvame ukukalwa ngasikhathi sinye.

Ukuhlolwa kuqukethe i- ukuhlolwa kwegazi, okwenziwa ekuseni phakathi kuka-7 ekuseni no-9 ekuseni Yilapho amazinga e-cortisol ephezulu kakhulu futhi ezinzile. Abasebenzi bezokwelapha abaphethe ukuhlolwa bazodonsa igazi elinemithambo yegazi, imvamisa lisuka endololwaneni.

Njengoba amazinga e-cortisol ehla enyuka usuku lonke, isivivinyo singenziwa kaningi ukuthola isithombe esinembe kakhudlwana sokukhiqizwa kwe-cortisol emaphakathi.

Izinga le-cortisol lingalinganiswa nasemchameni (ukulinganisa i-cortisol yamahhala yomchamo, ewusizo ikakhulukazi ekutholeni i-hypersecretion ye-cortisol). Ukwenza lokhu, umchamo kufanele uqoqwe esitsheni esihlinzekelwe le njongo isikhathi esingamahora angama-24.

Sizokuchazela inqubo, okubandakanya ukuqoqa wonke umchamo wosuku (ngokuwugcina endaweni epholile).

Ngaphambi kokuhlolwa (igazi noma umchamo), kunconywa ukuthi ugweme noma isiphi isimo esicindezelayo noma ukuzivocavoca umzimba. Udokotela futhi angacela ukumisa ukwelashwa okuthile okungaphazamisa umthamo we-cortisol (estrogen, androgens, njll.).

Egazini, inani elijwayelekile le-cortisol ehlolwe phakathi kuka-7 ekuseni no-9 ekuseni liphakathi kuka-5 no-23 μg / dl (ama-micrograms nge-deciliter ngayinye).

Emchameni, izinga le-cortisol evame ukutholakala liphakathi kuka-10 no-100 μg / 24h (ama-micrograms ngamahora angama-24).

Amazinga aphezulu e-cortisol angaba uphawu lwe:

• ICushing's syndrome (umfutho wegazi ophakeme, ukukhuluphala ngokweqile, i-hyperglycemia, njll.)

• isimila esibucayi noma esibi se-adrenal gland

• ukutheleleka okunamandla

• isifo se-capsular, i-infarction ye-myocardial

• noma i-cirrhosis yesibindi, noma ukuphuza ngokweqile okungapheli

Ngokuphambene nalokho, izinga eliphansi le-cortisol lingafana ne:

• ukungapheleli kwe-adrenal

• isifo sika-addison

• ukusebenza kabi kwe-pituitary noma i-hypothalamus

• noma kube ngumphumela wokwelashwa isikhathi eside kwe-corticosteroid

Udokotela kuphela ozokwazi ukuhumusha imiphumela futhi akunikeze ukuxilongwa (kwesinye isikhathi kudingeka ukuhlolwa okwengeziwe).