UMichael Greger, MD Mashi 27, 2014
Kungani ukusetshenziswa kwemifino njalo kubonakala kunciphisa amathuba okucindezeleka ngaphezu kwesigamu?
Ngo-2012, abacwaningi bathola ukuthi ukususa imikhiqizo yezilwane kuthuthukisa isimo sengqondo amasonto amabili. Abacwaningi basola i-arachidonic acid, etholakala ikakhulukazi ezinkukhuni nasemaqandeni, ngemiphumela engemihle empilweni yengqondo. Le asidi idala ukuvuvukala kobuchopho.
Kodwa ukuthuthukiswa kwemizwa esekelwe ezitshalweni kungase futhi kube ngenxa ye-phytonutrients etholakala ezitshalweni, ezeqa umgoqo wegazi-ubuchopho emakhanda ethu. Ukubuyekezwa kwakamuva ephephabhukwini I-Nutritional Neuroscience kuphakamisa ukuthi ukudla izithelo nemifino kungase kumelele ukwelashwa okungokwemvelo okungeyona invasive futhi okungabizi kanye nokuvimbela isifo sobuchopho. Kodwa kanjani?
Ukuze siqonde ucwaningo lwakamuva, sidinga ukwazi umsuka webhayoloji yokucindezeleka, okuthiwa i-monoamine theory of depression. Lo mbono wukuthi ukucindezeleka kungavela ngenxa yokungalingani kwamakhemikhali ebuchosheni.
Enye indlela izigidigidi zezinzwa ezisebuchosheni bethu ezingakhulumisana ngazo iwukulamula kwezimpawu zamakhemikhali ezibizwa ngokuthi ama-neurotransmitters. Amangqamuzana emizwa amabili awathinti ngempela – kukhona igebe elibonakalayo phakathi kwawo. Ukuvala leli gebe, lapho inzwa eyodwa ifuna ukushisa enye, ikhipha amakhemikhali kulelo gebe, kuhlanganise nama-monoamine amathathu: i-serotonin, i-dopamine, ne-norepinephrine. Lawa ma-neurotransmitters abe esebhukuda aye komunye umthambo ukuze amnake. Umsipha wokuqala uwamunca futhi ukuze aphinde asetshenziswe ngokuzayo lapho efuna ukukhuluma. Iphinde ikhiqize njalo ama-monoamine nama-enzyme, i-monoamine oxidase, iwathatha njalo futhi igcine inani elifanele kuphela.
Isebenza kanjani i-cocaine? Isebenza njenge-monoamine reuptake inhibitor. Ivimba inzwa yokuqala, iwuvimbele ekumunceni lawo makhemikhali amathathu aphoqeleka ukuthi acofe njalo ehlombe futhi asayinele ingqamuzana elandelayo. I-Amphetamine isebenza ngendlela efanayo kodwa futhi yandisa ukukhululwa kwama-monoamines. I-Ecstasy isebenza njenge-amphetamine, kodwa ibangela ukukhululwa okukhulu ngokuqhathaniswa kwe-serotonin.
Ngemva kwesikhashana, umsipha olandelayo ungase uthi, “Sekwanele!” futhi ucindezele ama-receptors akho ukuze wehlise ivolumu. Lokhu kuqhathaniswa nama-earplugs. Ngakho-ke kufanele siphuze imithi eminingi ukuze sithole umphumela ofanayo, bese kuthi lapho singayitholi, sizizwe sibi kakhulu ngoba ukusulelana okuvamile akudluli.
Ama-antidepressants kucatshangwa ukuthi ahlanganisa izindlela ezifanayo. Abantu abahlushwa ukucindezeleka banezinga eliphakeme le-monoamine oxidase ebuchosheni. Kuyi-enzyme ephula ama-neurotransmitters. Uma amazinga ethu e-neurotransmitter ehla, siyacindezeleka (noma kanjalo ithiyori iyahamba).
Ngakho, kuye kwasungulwa inani lezigaba ezahlukene zemithi. Ama-antidepressants e-Tricyclic avimba ukuphinda kuthathwe kwe-norepinephrine ne-dopamine. Bese kuba khona ama-SSRIs (Selective Serotonin Reuptake Inhibitors), njengeProzac. Manje siyazi ukuthi lokho kusho ukuthini - bamane bavimbele ukutholwa kabusha kwe-serotonin. Kukhona nezidakamizwa ezivele zivimbe ukutholwa kabusha kwe-norepinephrine, noma zivimbele ukuphinda kuthathwe kwe-dopamine, noma inhlanganisela yakho kokubili. Kodwa uma inkinga iyi-monoamine oxidase eningi, kungani ungavele uvimbe i-enzyme? Yenza i-monoamine oxidase inhibitors. Bakwenzile, kodwa i-monoamine oxidase inhibitors ibhekwa njengezidakamizwa ezinegama elibi ngenxa yemiphumela emibi engase ibe yingozi engozini.
Manje ekugcineni singakhuluma ngethiyori yakamuva yokuthi kungani izithelo nemifino kungathuthukisa isimo sethu sengqondo. Ama-Depression inhibitors atholakala ezitshalweni ezihlukahlukene. Izinongo ezifana nama-clove, i-oregano, isinamoni, i-nutmeg ivimbela i-monoamine oxidase, kodwa abantu abazidli izinongo ezanele ukuze belaphe ubuchopho babo. Ugwayi unomphumela ofanayo, futhi lokhu kungase kube esinye sezizathu zokukhula kwemizwa ngemva kokubhema ugwayi.
Kulungile, kodwa kuthiwani uma singafuni ukuhwebelana ngezimo ezimbi ngomdlavuza wamaphaphu? I-monoamine oxidase inhibitor etholakala kuma-apula, amajikijolo, amagilebhisi, iklabishi, u-anyanisi, netiye elihlaza empeleni ingathinta isayensi yezinto eziphilayo zobuchopho bethu ngokwanele ukuze sithuthukise isimo sethu sengqondo, futhi ingasiza ukuchaza ukuthi kungani labo abakhetha ukudla okusekelwe ezitshalweni bevame ukuba nomqondo ophakeme. isikolo sezempilo.
Amanye amakhambi abo emvelo okugula ngengqondo angancoma isafroni kanye ne-lavender.