La bilirubin is a sombala ayincibiliki emanzini anombala ophuzi, okubangelwa ukucekelwa phansielithwala umoya-mpilo. Udayi oyinhloko we bile. Ikhiqizwa kumaseli we amazinga nomnkantsha, bese ithuthwa ngomfutho wegazi nge-albumin iye esibindini. Uma sesikhona esibindini, sihlanganiswa ne-gluconic acid bese sincibilika emanzini. Emathunjini, i-conjugated bilirubin inika isitulo umbala onsundu.

Udokotela uzo-oda ukuhlolwa kwegazi kwe-bilirubin uma esola, isibonelo:

• i-hepatobiliary disorders: izimo ezithinta i- isibindi (isifo sokusha kwesibindi kohlobo oluvame kakhulu) kanye / noma imigudu yenyongo
• i-hemolytic syndromes (ebonakala ngokubhujiswa okungavamile kwamaseli abomvu egazi)
• noma i-jaundice yosana olusanda kuzalwa, ebizwa nangokuthi i-jaundice yosana olusanda kuzalwa

Ukuze kuhlolwe i-bilirubin, kufanele kwenziwe ukuhlolwa kwegazi, okubandakanya ukuhlolwa kwegazi le-venous. Kunconywa ukuthi ungadli noma uphuze okungenani amahora ama-4 ngaphambi kokuhlolwa kwegazi. Udokotela angase futhi acele isiguli ukuthi siyeke ukuphuza imithi ethile engase iphazamise imiphumela yokuhlolwa kwe-bilirubin.

Inani lesamba se-bilirubin egazini ngokuvamile liphakathi kuka-0,3 no-1,9 mg/dl (amamiligremu ngedesilitha ngayinye). Inani le-conjugated bilirubin (ebizwa nangokuthi i-bilirubin eqondile) ngokuvamile liphakathi kuka-0 no-0,3 mg/dl. 

Qaphela ukuthi amanani okuthiwa avamile we-bilirubin egazini angahluka kuye ngokuthi ilabhorethri eyenza ukuhlaziya.

Udokotela kuphela ongahumusha imiphumela futhi akunikeze ukuxilongwa.

Uma izinga le-bilirubin liphezulu, libizwa ngokuthihyperbilirubinémie.

Kungaba:

• ubukhulu befomu lamahhala (ngokukhiqiza ngokweqile noma ukuntuleka kokuhlanganiswa):

- izingozi transfusionnel

- i-anemia ye-hemolytic: i-toxic, imithi, i-parasitic hemolysis, njll.

- Isifo sikaGilbert (ukungajwayelekile kwe-bilirubin metabolism),

- i-jaundice yosana olusanda kuzalwa

I-Criggler-Najjar syndrome (ukuphazamiseka okuzuzwe njengefa kwe-bilirubin metabolism)

• ubukhulu befomu elihlanganisiwe (i-conjugated bilirubin idedelwa emjikelezweni lapho umzila ojwayelekile wokuphuma uvalekile):

– inyongo

i-neoplasia (umdlavuza)

- i-pancreatitis

- i-hepatitis enobuthi, i-alcohol hepatitis, i-viral hepatitis

- i-cirrhosis

Omunye uhlukanisa ikakhulukazi "i-jaundice ene-bilirubin yamahhala", okubangelwa ukubhujiswa ngokweqile kwamangqamuzana egazi abomvu (i-hemolysis) "ye-jaundice ene-conjugated bilirubin", kunalokho okuhlobene nesifo se-biliary noma se-hepatic.