I-Anaplastic oligoastrocytoma, noma i-anaplastic astrocytoma, iyisimila esibi sobuchopho. Ngokuqondile i-glioma, okungukuthi isimila esivela ezicutshini zemizwa, ebuchosheni noma emgogodleni. I-World Health Organisation ihlukanisa ama-gliomas kusuka ku-I kuye ku-IV, kuya nge-morphology yawo kanye nezinga lobubi. I-Anaplastic astrocytomas imelela ibanga lesi-III, phakathi kwamabanga I no-II athathwa njenge-benign ne-glioblastomas (ibanga IV). I-Anaplastic astrocytoma ingaba yinkimbinkimbi yesimila sebanga lesibili noma ikhule ngokuzenzekelayo. Unokuthambekela okuqinile kokuthuthukela ku-glioblastoma (ibanga IV) futhi isikhathi sokuphila cishe iminyaka emibili kuya kwemithathu, yize elashwa ngokuhlinzwa nange-radiotherapy / chemotherapy. I-Anaplastic astrocytomas kanye ne-glioblastomas kuthinta abantu abayi-5 kuya kwabangu-8 kubantu abayi-100 kubantu jikelele. (000)

Izimpawu eziningi ze-anaplastic oligoastrocytoma ziwumphumela wengcindezi eyandayo ebuchosheni, obangelwa yisimila uqobo noma ukwakheka okungajwayelekile kukashukela we-cerebrospinal. Izimpawu ziyahlukahluka kuye ngendawo kanye nosayizi wesimila:

• Ukukhubazeka kwenkumbulo, ukushintsha kobuntu kanye ne-hemiplegia lapho isimila sikhula ku-lobe engaphambili;
• Ukudlikizela, inkumbulo engasebenzi kahle, ukuxhumanisa nokukhuluma lapho use-lobe yesikhashana;
• Ukuphazamiseka kwezimoto nokungajwayelekile kwemizwa (ukuhayiza nokushisa) lapho kusengxenyeni ye-parietal lobe;
• Ukuphazamiseka okubonakalayo lapho isimila sihilela i-lobe ye-occipital.

Isizathu esiqondile se-anaplastic astrocytoma asikaziwa, kepha abacwaningi bakholelwa ukuthi kubangelwa ukuhlangana kokuthambekela kofuzo kanye nezimo zemvelo ezibangela lesi sifo.

I-Anaplastic oligoastrocytoma ivame kakhulu emadodeni kunabesifazane futhi ivame ukwenzeka phakathi kweminyaka yobudala engama-30 nengama-50. Kumele kuqashelwe nokho ukuthi lesi sifo kungenzeka sithinte izingane, imvamisa ziphakathi kweminyaka emihlanu nengu-5 ubudala. I-Anaplastic astrocytomas kanye ne-multiform glioblastomas (amamaki III no-IV) amele cishe i-9% yamathumba ebuntwana ohlelweni lwezinzwa oluphakathi (ama-10% ala mathumba abe ibanga I noma II). (80)

Izifo zofuzo ezofuzo ezifana nohlobo lwe-neurofibromatosis I (Recklinghausen's disease), Li-Fraumeni syndrome, kanye neBourneville tuberous sclerosis kwandisa ingozi yokuba ne-anaplastic astrocytoma.

Njengamagciwane amaningi omdlavuza, izinto ezithinta imvelo njengokuchayeka emisebeni ye-ultraviolet, imisebe ye-ionizing namakhemikhali athile, kanye nokudla ngendlela engafanele nokucindezeleka kubhekwa njengezici eziyingozi.

Ukwelashwa kwe-anaplastic oligoastrocytoma kuncike kakhulu esimweni esijwayelekile sesiguli, indawo yesimila kanye nejubane lokuqhubeka kwaso. Kubandakanya ukuhlinzwa, i-radiotherapy kanye ne-chemotherapy, kukodwa noma kuhlangene. Isinyathelo sokuqala ukwenza ukukhishwa kokuhlinzwa kwengxenye enkulu yesigaxa ngangokunokwenzeka (resection), kepha lokhu akwenzeki njalo ngenxa yemingcele ebalulwe ngenhla. Ngemuva kokuhlinzwa, ukwelashwa ngemisebe futhi mhlawumbe nokwelashwa ngamakhemikhali kusetshenziselwa ukuzama ukususa izinsalela zesimila, ngokwesibonelo uma amaseli amabi esabalele kwezicubu zobuchopho.

Isibikezelo sixhunyaniswe nesimo sempilo yesiguli, izici zesimila, nokuphendula komzimba ekwelashweni ngamakhemikhali nakwezokwelapha ngemisebe. I-Anaplastic astrocytoma inokuthambekela okuqinile kokuthuthukela ku-glioblastoma cishe eminyakeni emibili. Ngokwelashwa okujwayelekile, isikhathi sokusinda esiphakathi kwabantu abane-anaplastic astrocytoma yiminyaka emibili kuya kwemithathu, okusho ukuthi uhhafu wabo uzofa ngaphambi kwalesi sikhathi. (2)