Ukudla okunosawoti omningi, ngokuvamile okuyingozi empilweni, ezinhlobonhlobo zesimila se-murine kuvimbela ukukhula kwesimila ngoba kuvuselela ukusebenza kwesimiso somzimba sokuzivikela ezifweni, kubika iphephabhuku iFrontiers in Immunology. Ingabe ucwaningo luzosetshenziswa esikhathini esizayo?
Ukudla usawoti omningi kuyisici esiyingozi esaziwayo somfutho wegazi ophakeme nesifo senhliziyo nemithambo yegazi. Ucwaningo lwakamuva luphinde lwabonisa ukuthi usawoti omningi ekudleni ungakhuphula ulaka lwamangqamuzana omzimba omzimba, okuthuthukisa izifo ezizimele.
Ukudla okuyisishiyagalombili okuqukethe usawoti omningi kunalokho ocabanga ngakho
Nokho, nakuba amasosha omzimba anesivinini esikhulu enza umonakalo omkhulu kunokuhle emzimbeni onempilo, angathola umsebenzi owusizo esimweni somdlavuza.
Njengoba kuphakanyiswe ucwaningo lwaselabhorethri kumamodeli wamagundane, olwenziwa ithimba lamazwe ngamazwe eliholwa u-prof. U-Markus Kleinewietfeld ovela ku-VIB (Flemish Institute of Biotechnology), ukudla usawoti omningi kuvimbela ukukhula kwesimila. Umphumela ubonakala ungenxa yoshintsho ekusebenzeni kwamaseli e-myeloid lineage suppression cell (MDSCs), adlala indima ebalulekile ekulweni nomdlavuza. Ama-MDSC acindezela ukusebenza kwamanye amaseli omzimba, kodwa endaweni enosawoti, imiphumela yawo evimbelayo iba buthaka futhi ezinye izinhlobo zamaseli zihlasela isimila ngamandla. Umphumela ofanayo wemvelo enosawoti ku-MDSC ubuye wabonwa lapho amaseli wesimila somuntu ekhulisiwe.
Ngokusho kwababhali, ucwaningo olwengeziwe lungase luthuthukise imiphumela yokwelashwa komdlavuza ngendlela elula neshibhile kakhulu. Kodwa okokuqala, udinga ukuqonda ngokugcwele lo mphumela kanye nezinqubo eziningiliziwe zamangqamuzana. Kuyaziwa ukuthi usawoti ophezulu ukhuthaza, isibonelo, ukuthuthukiswa komdlavuza wesisu.