Amaqiniso ama-5 ngezidakamizwa zokuthuthukisa ukugaya

Ukudla ngokweqile akubizwa ngesifo somhlaba owondliwe ngeze. Indlela yokuphila yesimanje inikela kuphela ekuthuthukiseni lo mkhuba. Amadina afike ngemuva kwesikhathi kulo lonke isonto lokusebenza. Imikhosi yemikhosi enenala yokudla okuyingozi. Ukuhlolwa kwama-movie omndeni ngamasemishi nokudla okulula. Intengo yenjabulo yesikhashana yama-buds wokunambitha imvamisa iyizimpawu ezingathandeki zokudla ngokweqile: isisindo ngemuva kokudla, ukungakhululeki esiswini, ukuqunjelwa, ukuqothuka. Futhi, uma umzimba ungabekezeleli, imishanguzo yokuthuthukisa ukugaya iyasiza. Zisebenza kanjani? Ingabe konke kuyasebenza? Ngubani okufanele azithathe futhi nini?

Iqiniso # 1. Ama-enzyme ayadingeka ekugayeni okujwayelekile

Kuyaziwa ukuthi umuzwa wokusutha uza kancane kancane. Njengoba isisu sigcwele ukudla, i-hormone esuthayo i-leptin iqala ukukhiqizwa. Kuthinta ukuphela kwezinzwa esiswini, bese kuthunyelwa isiginali ebuchosheni ukuthi umzimba ugcwele. Ngokwesilinganiso, inqubo ithatha imizuzu engama-301. Lokhu kwanele ukuba nesikhathi sokugcwalisa isisu sakho ngokudla okwengeziwe.

Ukugcwala ngokweqile kuzenza zizwakale ngezinhlobonhlobo zemizwa. Sihlushwa ubunzima esiswini, ukuqunjelwa, ukungakhululeki okujwayelekile. Lokhu kungenxa yokuthi awekho ama-enzyme wokugaya akwanele akhiqizwa amanyikwe, ngoba umthamo wokudla mkhulu kakhulu.

Kulokhu, idinga izinsiza ezingeziwe. Umsebenzi wabo uthathwa yimithi yokwenza ngcono ukugaya, noma amalungiselelo enzyme. Banikezela ngokutholakala okudingekayo kwama-enzyme okucubungula ukudla futhi kube neqhaza ekwamukelweni okufanele kwezakhamzimba.

Ngokuphikisana nesizinda sokudla okungafanele, okungafanele, kungavela izinkinga ezinkulu kakhulu. Isibonelo, isilungulela, isicanucanu, isifo sohudo, ubuhlungu besisu. Ngakho-ke, lonke uhlelo lokugaya luyahlupheka.

Iqiniso # 2. Kudingeka ama-enzyme ngaso sonke isikhathi sokudla, kungakhathalekile ukuthi kungakanani ivolumu

Ama-pancreas akhiqiza ama-enzyme ngaso sonke isikhathi sokudla, noma ngabe kukhona isidlo esincane. Ngasikhathi sinye, sine-enzyme yaso elungiselelwe uhlobo ngalunye lwezakhi. Ngakho-ke, i-lipase ihlukanisa amafutha, i-protease isiza ukugaya amaprotheni, i-amylase iguqula ama-carbohydrate ayinkimbinkimbi abe lula.

Uma ubunzima nokungakhululeki kwenzeka ngezikhathi ezithile ngemuva kokudla, lokhu kungakhombisa ukuthi awekho ama-enzyme anele akhiqizwa amanyikwe. Kungaba nezizathu eziningi: ukudla okungafanele, ukushintshashintsha kwesifiso, izinguquko ezihlobene nobudala, ukwehluleka kwamahomoni, izifo ezihambisanayo.

Kungakho amanyikwe adinga abasizi ngendlela yokulungiselela ama-enzyme. Kubalulekile ukuqaphela ukuthi awunciphisi umkhiqizo wawonhlobo 2, okukuvumela ukuthi ucubungule ukudla kahle futhi kahle. Futhi njengoba zifaka ama-enzyme omzimba omzimba, kufanele zenze ngokudla kube sengathi zikhiqizwe yizo uqobo.

 

Iqiniso # 3. Ama-enzyme asebenza emathunjini, hhayi esiswini

Sonke siyakhumbula ukuthi inqubo yokugaya iqala ngokushesha nje lapho sesithumele ucezu lokuqala lokudla emlonyeni wethu. I-sali iqukethe ama-enzyme aqala ukugaya, athambise ukudla futhi akusize kudlulele phambili ezansi. Isisu siqala futhi ukukhipha ujusi wesisu wokuhlukanisa ukudla.

Kepha ukwahlukaniswa okuyinhloko kokudla akwenzeki esiswini, kepha ngemuva kwesikhashana-lapho kungena emathunjini. Ngasikhathi sinye, kwakhiwa izakhi ezifanayo zokuthi umzimba kufanele ube nesikhathi sokuthola ivolumu ephelele kakhulu. Uma kukhona ubunzima noma ukungakhululeki ngemuva kokudla, amalungiselelo e-enzyme angasetshenziswa lapha. Kepha akubona bonke abakwazi ukufinyelela emathunjini ngasikhathi sinye ngokudla noma benziwe basebenze kancane kakhulu. Ngemuva kwalokho umzimba ulahlekelwa isabelo esibambekayo "sephethiloli", ngakho-ke isisindo nokungakhululeki ngemuva kokudla kungahlala isikhashana.

Mayelana nalokhu, ukulungiselela i-enzyme uCreon® I-10000 ingaba umsizi othembekile. Ingena emathunjini ngasikhathi sinye nokudla futhi iyasebenza ngemuva kwemizuzu engu-15, isusa ubunzima ngemuva kokudla, ukungakhululeki esiswini, ukuqunjelwa, ukukhuphuka komoya nokwakheka okunye okungathandeki.3 Kepha okubaluleke kakhulu, izakhamzimba zimunca kahle nangesilinganiso esifanele. 

 

Iqiniso # 4. Ama-Minimicrospheres amafomethi wesimanjemanje wama-enzyme4

Amalungiselelo amaningi e-enzyme aqukethe into eyodwa efanayo esebenzayo - i-pancreatin. Ukwakheka kwama-enzyme awo kuhambisana ngokuphelele nalawo akhiqizwa amanyikwe. Ubuqili bulele eqinisweni lokuthi akuwona wonke umuthi okwazi ukuletha into esebenzayo njengoba nje kuhlosiwe - emathunjini.

Izinhlobo ezivame kakhulu zokukhishwa kwama-enzyme ngamathebulethi nama-dragees. Kepha banenkinga enkulu. Ngenxa yefomu lonke, amaphilisi awakwazi ukuxubana ngokulinganayo nokudla esiswini bese edlulela emathunjini ngengxenye ngayinye yawo. Kungakho kuphela ingxenye yazo ingena emathunjini kanye nokudla, okungenzeka kunganeli ukugaywa okugcwele kwakho konke okudliwayo. Ngasikhathi sinye, amanye ama-enzyme angahlala esiswini, futhi sesivele sathola ukuthi amalungiselelo enzyme aba lusizi esiswini. Ngaphezu kwalokho, amaphilisi kungaba nzima ukuwaginya, ikakhulukazi ezinganeni ezincane nasebekhulile. Ukuzama ukuchoboza noma ukugaya kuzoba yiphutha, ngoba lokhu kuzobhubhisa igobolondo lokuvikela lethebulethi, futhi imvelo ene-asidi esiswini izobhubhisa ama-enzyme.

Enye into amaphilisi "ahlakaniphile" weCreon yokugaya®. I-capsule ngayinye enjalo iqukethe amakhulu ezinhlayiya-i-minimicrospheres, enobubanzi obulinganiselwa ku-1.15Mm3. Ama-minimicrospheres anelungelo lobunikazi futhi aqukethe kuphela ekubunjweni kweCreon®5. Kukhonjiswa ukuthi izinhlayiya ze-enzyme zincane, umuthi usebenza ngempumelelo kakhulu3 ingasebenza.

Kuleli fomu, lixubana kangcono nokudla esiswini futhi ngasikhathi sinye lidlulela emathunjini. Okubaluleke kakhulu, ngaphezu kwe-capsule, indawo ngayinye encane ivikelwe ngegobolondo elingazweli i-asidi. Ibavumela ukuba "basinde" endaweni ene-asidi esiswini futhi bahambise ama-enzyme asebenzayo ngqo emathunjini3. Ngenxa yale ndlela yokusebenza, ukuthatha uCreon® kusiza ukugaya kube ngokwemvelo ngangokunokwenzeka, okuqinisekisa ukugaywa okuphelele kokudla nokwenziwa kwawo wonke umsoco.3

Iqiniso # 5. Ukuntuleka kwama-enzyme kuthinta umzimba wonke

Ukushoda kwama-enzyme kuthinta wonke umzimba6. Ukudla ngokweqile kulimaza nezinye izinhlelo zomzimba. Ukugcwalisa ngokudla okungenakulinganiswa, isisu ngokulalela sinweba izindonga futhi sande ngosayizi. Ngakho-ke ingafaka ingcindezi ezithweni zesifuba, ubende, amathumbu futhi iphazamise umsebenzi wabo ogcwele.

Ngokuhamba kwesikhathi, ukudla ngokweqile njalo kungaholela ekukhuluphaleni6. Amakhilogremu angeziwe anika umthwalo owengeziwe enhliziyweni6. Ngemuva kwakho konke, yena, njengempompo enamandla, kufanele apompe igazi ngendlela ende.

Ukudla ngokweqile nokukhuluphala ngokweqile kungaholela ekuphazamisekeni komzimba7. Amalunga nomgogodla uhlangabezana nomthwalo omkhulu. Izinguquko eziyingozi kakhulu zenzeka esibindini. Eqinisweni, izicubu zesibindi ziphenduka kancane kancane zibe ngamafutha7. Isifo sikashukela kanye nokuqwasha kungaqala ukukhula8.

Ukusiza umzimba ukugaya ukudla, kudinga amalungiselelo enzyme. Basiza ukusungula izinqubo zokugaya nokugaya umzimba, okunikela emsebenzini wokuhleleka kahle kwezinye izitho nezinhlelo.

Ngezimpawu zokudla ngokweqile, 1-2 amaphilisi weCreon® I-10000 yanele - leli inani elifanele lama-enzyme wokuthuthukisa ukugaya. Ungathatha uCreon® kuwo wonke umuntu noma ngasiphi isikhathi, ngisho nabesifazane abakhulelwe kanye nezingane ezincane kusukela bezalwa9. Kungcono ukwenza lokhu ngesikhathi sokudla noma ngokushesha ngemuva, ngenani elincane lamanzi9.

Ngasizathu simbe noma kwesinye, umzimba uvame ukungabi nawo ama-enzyme wokugaya ukudla. Indlela esheshayo yokwenzela ukuntula kwabo ukusiza ukulungiselela ama-enzyme. Ngasikhathi sinye, kubalulekile ukuthi basebenze ngokushesha, ngobunono nangendlela efanele ngangokunokwenzeka. Lokhu kuyisihluthulelo sokugaya okugcwele nokuhlanganiswa okukhiqizayo kwezinto eziwusizo. Futhi kanye nabo - impilo enhle kanye nempilo yomzimba wonke wonkana.

1. I-Poltyrev SS Physiology yokugaya ukudla: incwadi yokufunda. ibhukwana. - EMoscow: Isikole esiphakeme, 2003. - k. 386.

2. I-Belmer SV, i-Gasilina TV Ukwehluleka kokugaya ukudla kwamanyikwe ezinganeni. Indlela ehlukile / / Umdlavuza webele, Umama nengane. Izifo zezingane, 2007. - Cha. 

3.ULöhr JM, uHummel FM, uPirilis KT et al. Izakhiwo zamalungiselelo e-pancreatin ahlukene asetshenziswa ekungeneni kwe-pancreatic exocrine // Eur J Gastroenterol Hepatol., 2009; 21 (9): 1024-31.

4. IGubergrits NB, Yandisa amakhono okwelapha amalungiselelo we-enzyme: inqubekela phambili isuka kumathebulethi iye kuma-minimicrosferon, “RMZH” No. 24 of 19.12.2004, p. 1395.

5. Umuthi okuyiwo kuphela we-pancreatin osesimweni sama-minimicrospheres obhaliswe endaweni yaseRussian Federation, ngokweRejista Kahulumeni Yezinhlangano Zezomthetho kusukela ngomhla ka-05.04.2019 / Umthombo http://www.freepatent.ru/images/patents/52 /2408257/patent-2408257.pdf RU 2 408 364 C2 entry from 17.04.2019 and http://www.freepatent.ru/images/patents/18/2440101/patent-2440101.pdf RU 2 440 101 C2 entry from 17.04.2019 .XNUMX.

6. Izinkinga zokugaya ukudla zeLyubimova ZV. Izindlela eziphumelelayo zokwelashwa. - EMoscow: Eksmo, 2009. - k. 117.

7. UTrofimov S. Ya. Uhlelo lokugaya ukudla. Izifo zamathumbu. - M.: Prosveshchenie, 2005. - k. 201.

8. I-Yakovlev MV I-anatomy yomuntu ejwayelekile: amanothi enkulumo. - EMoscow: Isikole Esiphezulu, 2003. - k. 312.

9. Imiyalo yokusetshenziswa kwezokwelapha komuthi iCreon® 10000 kusuka ngomhlaka 11.05.2018.

Le nto yakhiwa ngokuxhaswa yi-Abbott Company ngenhloso yokwandisa ukuqwashisa ngesiguli ngesimo sempilo.

RUCRE191033 kusuka ngo-17.04.2019

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