Isizathu esivame kakhuluukwehluleka kwezinso okungapheli isifo sikashukela, kungakhathaliseki ukuthi siwuhlobo 1 noma 2. Lokhu kungenxa yokuthi isifo sikashukela silimaza imithambo yegazi emincane, kuhlanganise naleyo engaphakathi ezinso. Ngokuvamile, izifo ezibangela izinkinga zenhliziyo nazo ziyizici eziyingozi zesifo sezinso. Ukuguga, umfutho wegazi ophakeme, ukukhuluphala, isifo sikashukela, ukubhema kanye ne-cholesterol ephansi ye-HDL ("i-cholesterol enhle")¹. Ezinye izici eziyingozi zingabangela isifo sezinso esingamahlalakhona, kuhlanganise nalokhu okulandelayo:

• I-pyelonephritis (ukutheleleka kwezinso);
• Isifo sezinso se-polycystic;
• izifo ze-autoimmune, njenge-systemic lupus erythematosus;

• Ukuvinjelwa komgudu womchamo (njengaku-prostate ekhulisiwe);
• Ukusetshenziswa kwezidakamizwa ezigaywe yizinso, njengemithi ethile yokwelapha umdlavuza.