Ucwaningo selunikeze amandla inqubekelaphambili enkulu ku ukwelashwa kwezimpawu du lupus. Nokho, alikho ikhambi eliqinisekile lalesi sifo. Imithi ithuthukisa izinga lempilo ngokunciphisa ukushuba kwezimpawu, yehlise ingcuphe yezinkinga nokwandisa isikhathi sokuphila.

Ngokufanelekile, ukwelashwa kwe- lupus ngemithi emincane ngangokunokwenzeka nangesikhathi esifushane, ukudambisa ukuqubuka. Abanye abantu abawudingi umuthi, abanye bawusebenzisa kuphela uma kudingeka noma isikhathi esifushane (ukuqubuka), kodwa abantu abaningi kudingeka baphuze imithi isikhathi eside.

Izidakamizwa zokwelapha

Imithi yobuhlungu (izidakamizwa ezingezona ukuvuvukala). I-Acetaminophen (Tylenol®, Atosol®) kanye nezidakamizwa ezilwa nokuvuvukala²⁵ i-over-the-counter (ibuprofen, Advil®, noma i-Motrin) ingasetshenziswa ukudambisa izinhlungu amalunga omzimba, lapho i-lupus ingenamandla kakhulu noma ama-flare-ups angekho kakhulu. Nokho, odokotela abatusi ukuthi abantu abane- i-lupus enzima kakhulu thatha ama-over-the-counter relievers wodwa. Le mithi ingandisa ingozi yezinkinga ezivela ku-lupus, ikakhulukazi ukulimala kwezinso. Kungase kuthathe isikhashana ukuthola imithi elwa nokuvuvukala efanele futhi ulungise umthamo nodokotela wakho.

Ama-Corticosteroids. I-Corticosteroids, ikakhulukazi i-prednisone ne-methylprednisone, imithi elwa nokuvuvukala ephumelela kakhulu ekwelapheni. lupus, lapho isifo sithinta izitho eziningana. Isetshenziswe kusukela ekuqaleni kwawo-1960 ngokumelene ne-lupus, i-prednisone (i-Deltasone®, i-Orasone®) ngokushesha yaba umuthi obalulekile wokuthuthukisa izinga lempilo yeziguli. Kuyasiza ukunciphisa ukuvuvukala nokulawula izimpawu, ikakhulukazi ngokuqubuka. Kodwa-ke, i-corticosteroids ethathwe ngemithamo emikhulu noma isikhathi eside ingabangela uchungechunge lweOkuqhamuka uma udla imishanguzo, okuhlanganisa ukuqala kwemihuzuko, ukushintsha kwemizwelo, isifo sikashukela^25-26 , izinkinga zokubona (i-cataract), ukwanda komfutho wegazi kanye namathambo abuthakathaka (i-osteoporosis). Umthamo ulungiswa kahle nodokotela ukuze kutholwe imiphumela emibi embalwa ngangokunokwenzeka. Esikhathini esifushane, imiphumela emibi eyinhloko ye-corticosteroids ukuzuza kwesisindo nokuvuvukala kobuso nomzimba (i-edema). Ukusebenzisa izithako ze-calcium ne-vitamin D kusiza ukunciphisa ingozi ye-osteoporosis.

Amakhilimu nokwelashwa kwendawo. Ngezinye izikhathi amarashi aphathwa ngokhilimu, ngokuvamile nge-corticosteroids.

Izidakamizwa zokulwa nomalaleveva. IHydroxychloroquine (Plaquenil®) ne-chloroquine (Aralen®) - imithi esetshenziselwa ukwelapha umalaleveva – ziyasebenza ekwelapheni lupus lapho izidakamizwa ezingezona ukuvuvukala zinganele. Banciphisa ubuhlungu nokuvuvukala emalungeni futhi basize ekwelapheni ukuqubuka. Noma iyiphi yale mithi ingathathwa kusukela entwasahlobo kuya ekwindla ukuze kuvinjelwe ukuqala kwezilonda zesikhumba. sun. IHydroxychloroquine nayo isetshenziswa njengokwelashwa okuyisisekelo ukuvimbela ukuphindeka. Imiphumela eyinhloko yale mithi ubuhlungu besisu kanye nesicanucanu.

Ama-immunosuppressants. Ama-immunosuppressive agents anciphisa umsebenzi wamasosha omzimba aqondiswe ezithweni zawo kanye nezicubu. Le mithi enamandla isetshenziswa engxenyeni encane yabantu lapho i-prednisone ingasizi ngezimpawu noma lapho idala imiphumela emibi kakhulu. Ziyadingeka uma lupus kuthinta ukusebenza kwe isikhumba noma uhlelo ukwesaba. Okuvame ukusetshenziswa kakhulu yi-cyclophosphamide (Cytoxan®), i-azathioprine (Imuran®) ne-mycophenolate mofetil (Cellcept®). Kwezinye iziguli, i-methotrexate (i-Folex®, i-Rheumatrex®) nayo ingasetshenziswa ngemithamo ephansi njengendlela yokwelapha yesondlo. Le mishanguzo nayo inengxenye yayo yemiphumela engemihle, ebaluleke kakhulu esengozini enkulu yokuthola izifo kanye nengozi enkulu yokuba nomdlavuza. Isidakamizwa esisha, i-belimumab (i-Benlysta) singase sisebenze kwezinye izimo ze-lupus; imiphumela yayo engemihle engaba khona isicanucanu, isifo sohudo nomkhuhlane²⁵.

Izincwajana zemininingwane

I-Immunoglobulin infusions. Amalungiselelo e-Immunoglobulin (antibody) atholakala egazini labanikeli. Uma zilawulwa ngemithambo yegazi, zinesenzo sokulwa nokuvuvukala njengoba zinciphisa kancane amasosha omzimba, okungukuthi amasosha omzimba angajwayelekile ajikela umzimba futhi abambe iqhaza ekulweni nokuvuvukala. lupus. I-Immunoglobulin infusions igcinelwe izimo ze-lupus ukumelana nezinye izindlela zokwelapha, njenge-corticosteroids.