Izidakamizwa ezivimbela umsebenzi we-immune system protein - i-gamma interferon ivimbela ukuthuthukiswa kwe-melanoma - umdlavuza wesikhumba oyingozi - ngokusho kososayensi base-US ephephabhukwini le-Nature.
Ukuchayeka ekukhanyeni kwe-ultraviolet nemisebe yizimbangela ezimbili eziyinhloko zokukhula kwe-melanoma - umdlavuza wesikhumba oyingozi kakhulu. Ngeshwa, kuze kube manje izindlela zamangqamuzana zokuthuthukiswa kwalo mdlavuza azikaqondwa ngokugcwele.
U-Glenn Merlino kanye nozakwabo be-National Cancer Institute e-Bethesda bafunde imiphumela yemisebe ye-UVB kumagundane. Ososayensi baye babonisa ukuthi i-UVB ibangela ukuthi ama-macrophage ageleze esikhumbeni. Ama-Macrophage awuhlobo lwamangqamuzana amhlophe egazi, amangqamuzana akhiqiza i-interferon gamma, iphrotheni amakhemikhali abonisa ukuthuthukiswa kwe-melanoma.
Ukuvinjelwa komsebenzi we-interferon gamma (okungukuthi uhlobo lwe-interferon II) ngosizo lwamasosha omzimba afanelekile kuvimbela ukukhula okungavamile kwamangqamuzana esikhumba nokuthuthukiswa komdlavuza, ukuvinjelwa komsebenzi we-interferon I akunawo umphumela onjalo.
Ama-interferon ohlobo lwe-I abonwa njengamaprotheni alwa nomdlavuza futhi enye yawo, i-interferon alpha, isetshenziselwa ukwelapha i-melanoma. Ukutholakala kokuthi i-gamma interferon inomphumela ophambene futhi ikhuthaza ukukhula komdlavuza kuyamangaza. Ukuvinjelwa kwe-gamma interferon noma amaprotheni okuwathintayo kubonakala kuyinhloso enhle yokwelashwa kwe-melanoma. (PAP)