La imisipha biopsy ukuhlola okubandakanya ukukhipha ucezu lomsipha ukuze uluhlole.

I-muscle biopsy yenziwa ngenhloso yokuhlonza noma ukuthola izimo eziningi, okuhlanganisa:

• we izicubu ezixhumene nezifo zemithambo yegazi
• izifo ezithinta imisipha, njenge I-Toxoplasmosis
• ukuphazamiseka kwemisipha, njenge ukuqina kwemisipha noma i-myopathy yokuzalwa
• noma ukukhubazeka kwe-metabolic izicubu zomzimba (i-myopathies ye-metabolic).

I-muscle biopsy yenziwa esikhungweni esikhethekile. Udokotela wenza i-anesthesia yendawo esikhumbeni, ezingeni lesayithi lesampula, ngaphambi kokwenza i-biopsy. Ukukhethwa kwemisipha kuya ku-biopsy kuqondiswa ukuhlolwa komtholampilo kadokotela futhi kungadingausebenzisa i-MRI or isithwebuli semisipha ngaphambili. Qaphela ukuthi umsipha ozokwenziwa i-biopsy kufanele ubonise ukulimala okuphawulekayo, kodwa akufanele ulimele kakhulu, ukuze udokotela akwazi ukuthola izicubu ezanele ukuze azihlaziye.

Uhlobo lokuqala lwe-biopsy luhilela ukufaka inaliti emsipha (ongaphezulu) futhi uyisuse ngokushesha lapho ucezu lomsipha lususiwe.

Olunye uhlobo luhilela ukusika (amasentimitha angu-1,5 kuya ku-6) esikhumbeni nasemsipha ukuze kukhishwe ucezu lwezicubu zomzimba. I-suture yenziwa ukuvala i-incision. Akudingekile ukuba ube esiswini esingenalutho. Imiphumela engemihle ayibalulekile, ngokuvamile inxeba kanye nomuzwa wokuqina.

Izingcezu zemisipha eziqoqiwe ekugcineni zithunyelwa elabhorethri ukuze zihlaziywe (ukufundwa kwezicubu zemisipha ngaphansi kwesibonakhulu, ukuhlaziya amaprotheni emisipha nge-immunohistochemistry, ukuhlaziywa kofuzo, njll.). Ukuhlolwa ngaphansi kwe-microscope kungakhomba uhlobo lwezilonda (izimpawu ze-necrosis zingase zibonakale ikakhulukazi).

I-muscle biopsy ingasiza udokotela ukuthi ahlonze izimo ezilandelayo, kuhlanganise:

• a i-atrophy (ukulahlekelwa kwemisipha)
• a i-myopathy yokuvuvukala (ukuvuvukala kwezicubu zomzimba)
• a I-Duchenne muscular dystrophy (isifo sofuzo esibonakala ngokuba buthaka nokonakala kwamaseli emisipha ngenxa yokuntuleka kwe-protein dystrophin) noma enye i-myopathy yofuzo
• a i-necrosis yemisipha

Kuye ngemiphumela, ngakho-ke udokotela angase abone isifo futhi angase asikisele ukwelashwa okwanele noma ukuphathwa okufanele.