I-Cushing's syndrome isifo sohlelo lwe-endocrine esixhunyaniswe nokuchayeka komzimba emazingeni aphezulu kakhulu e-cortisol, ihomoni ekhishwa izindlala ze-adrenal. Isici saso esikhulu ukukhuluphala komzimba ongaphezulu nobuso bomuntu othintekile. Ezimweni eziningi, i-Cushing's syndrome ibangelwa ukuphuza izidakamizwa ezilwa nokuvuvukala. Kodwa futhi ingaba nembangela yemvelaphi engapheli, njengesifo sika-Cushing, esingavamile kakhulu, kusukela esimweni esisha kuya kweshumi nantathu kubantu abayizigidi ngonyaka, ngokusho kwemithombo. (1)

Amazinga e-cortisol aphezulu ngokungavamile abangela inqwaba yezimpawu nezimpawu. Okuhlaba umxhwele kakhulu ukuzuza kwesisindo kanye noshintsho ekubukeni komuntu ogulayo: amafutha aqoqana emzimbeni ophezulu nasentanyeni, ubuso buba yindilinga, bukhukhumeze futhi bubomvu. Lokhu kuhambisana nokulahlekelwa kwemisipha ezingalweni nasemilenzeni, kangangokuthi le "atrophy" ingaphazamisa ukuhamba komuntu othintekayo.

Ezinye izimpawu zibonakala njengokuncipha kwesikhumba, ukubonakala kwama-stretch marks (esiswini, emathangeni, ezinqeni, ezingalweni nasemabeleni) kanye nemihuzuko emilenzeni. Umonakalo obalulekile ongokwengqondo ngenxa yesenzo sobuchopho se-cortisol akufanele kunganakwa noma: ukukhathala, ukukhathazeka, ukucasuka, ukuphazamiseka kokulala nokugxilisa ingqondo nokucindezeleka kuthinta izinga lokuphila futhi kungaholela ekuzibulaleni.

Abesifazane bangaba nezinduna kanye nokukhula kwezinwele ngokweqile futhi bahlangabezane nokuphazamiseka kokuya esikhathini, kuyilapho ukuya ocansini kwabesilisa nokuzala kuncipha. I-osteoporosis, izifo, i-thrombosis, umfutho wegazi ophakeme kanye nesifo sikashukela yizinkinga ezivamile.

I-Cushing's syndrome ibangelwa ukuchayeka ngokweqile kwezicubu emzimbeni kumahomoni e-steroid, kuhlanganise ne-cortisol. I-Cushing's syndrome ngokuvamile iphumela ekuthatheni ama-synthetic corticosteroids ngemiphumela yawo eqeda ukuvuvukala ekwelapheni isifuba somoya, izifo ezivuthayo, njll., ngomlomo, njengesifutho noma njengesigcobo. Khona-ke imvelaphi yangaphandle.

Kodwa imvelaphi yayo ingaba yi-endogenous: i-syndrome ibangelwa ukukhishwa ngokweqile kwe-cortisol nge-adrenal gland eyodwa noma zombili (etholakala phezulu kwezinso). Lokhu kwenzeka lapho isimila, esiyingozi noma esiyingozi, sikhula ku-adrenal gland, ku-pituitary gland (esokhakhayini), noma kwenye indawo emzimbeni. Lapho i-Cushing's syndrome ibangelwa isimila esiyingozi endlaleni ye-pituitary (i-pituitary adenoma), ibizwa ngokuthi i-Cushing's disease. Isimila sikhiqiza i-hormone ye-corticotropin eyeqile i-ACTH ezoshukumisa izindlala ezikhiqiza i-adrenal futhi ngokungaqondile ukukhiqizwa ngokweqile kwe-cortisol. Isifo sikaCushing sibalelwa ku-70% wazo zonke izifo ezingapheli (2)

Izimo eziningi ze-Cushing's syndrome azizuzwa ngofuzo. Kodwa-ke, lokhu kungenzeka ngenxa yokuthambekela kofuzo ekuthuthukiseni izimila ku-endocrine, adrenal, ne-pituitary gland.

Abesifazane banamathuba aphindwe kahlanu okuthola i-Cushing's syndrome okubangelwa i-adrenal noma i-pituitary tumor. Ngakolunye uhlangothi, amadoda asengozini ngokuphindwe kathathu kunabesifazane uma imbangela kuwumdlavuza wamaphaphu. (2)

Umgomo wanoma yikuphi ukwelashwa kwe-Cushing's syndrome uwukuphinda ulawule ukukhishwa ngokweqile kwe-cortisol. Lapho i-Cushing's syndrome ibangelwa izidakamizwa, i-endocrinologist ilungisa ukwelashwa okuyimbangela. Uma kungumphumela we-tumor, ukwelashwa ngokuhlinzwa (ukususwa kwe-adenoma ku-pituitary gland, i-adrenalectomy, njll.), i-radiotherapy kanye ne-chemotherapy, isetshenziswa. Uma kungenakwenzeka ukusiqeda ngokuphelele isimila esiyimbangela, izidakamizwa ezivimbela i-cortisol (ama-anticortisolics) noma ama-inhibitors ehomoni i-ACTH zingasetshenziswa. Kodwa zintekenteke ukuzisebenzisa futhi imiphumela yazo engemihle ingaba mibi, iqala ngengozi yokungasebenzi kahle kwezindlala ze-adrenal.