Ukuthola ama-antidepressants afanele kunzima. Azisebenzi ngokushesha, futhi ngokuvamile kufanele ulinde amasonto ambalwa ukuze ekugcineni uthole ukuthi umuthi awusizi. Isazi sokusebenza kwengqondo u-Anna Cattaneo sathola indlela yokunquma ukwelashwa okufanele ekuqaleni.
Ekucindezelekeni okukhulu, ngokuvamile kuba nengozi yangempela yokuzibulala. Ngakho-ke, kubaluleke kakhulu ukuthola indlela efanele yokwelashwa, kucatshangelwa izici zomuntu ngamunye zesiguli ngasinye, hhayi "ngokungahleliwe".
Eminyakeni yamuva, odokotela nososayensi baye bafinyelela esiphethweni sokuthi ukuphazamiseka kwengqondo okuningi, ikakhulukazi - ukucindezeleka okuhambisana nokuvuvukala okungapheliemzimbeni. Ukuvuvukala ngemva kokulimala noma ukugula kuyinto evamile ngokuphelele, kubonisa kuphela ukuthi isimiso sethu somzimba sokuzivikela ezifweni silwa namagciwane futhi silungisa umonakalo. Ukuvuvukala okunjalo kutholakala kuphela endaweni ethintekile yomzimba futhi kudlula ngokuhamba kwesikhathi.
Kodwa-ke, izinqubo zokuvuvukala ezihlelekile zesistimu zithinta wonke umzimba isikhathi eside. Ukuthuthukiswa kokuvuvukala kukhuthazwa: ukucindezeleka okungapheli, izimo zokuphila ezinzima, ukukhuluphala nokungondleki. Ubudlelwano phakathi kokuvuvukala nokudangala bukabili - basekelana futhi bayaqinisana.
Ngosizo lokuhlaziya okunjalo, odokotela bazokwazi ukunquma kusengaphambili ukuthi izidakamizwa ezijwayelekile ngeke zisize isiguli.
Izinqubo zokuvuvukala zifaka isandla ekuthuthukiseni lokho okubizwa ngokuthi ukucindezeleka kwe-oxidative, okwenzeka ngenxa ama-radicals mahhala ngokweqile abulala amangqamuzana obuchopho futhi aphule ukuxhumana phakathi kwabo, ekugcineni okuholela ekuthuthukiseni ukucindezeleka.
Izazi zokusebenza kwengqondo ezivela e-UK, eziholwa ngu-Anna Cattaneo, zanquma ukuhlola ukuthi kungenzeka yini ukubikezela ukusebenza kwezidakamizwa zokucindezeleka usebenzisa ukuhlolwa kwegazi okulula okukuvumela ukuthi unqume izinqubo zokuvuvukala.1. Babheka idatha yango-2010 eyayiqhathanisa izici zofuzo (nokunye okwengeziwe) ezithinta indlela ama-antidepressants asebenza ngayo.
Kuvele ukuthi iziguli ngubani umsebenzi wezinqubo zokuvuvukala udlule umkhawulo othile, ama-antidepressants avamile awazange asebenze. Esikhathini esizayo, besebenzisa ukuhlaziya okunjalo, odokotela bazokwazi ukunquma kusengaphambili ukuthi izidakamizwa ezijwayelekile ngeke zisize isiguli nokuthi izidakamizwa ezinamandla noma inhlanganisela yezimbalwa, kuhlanganise nezidakamizwa ezilwa nokuvuvukala, kufanele zibekwe ngokushesha.
1 A. Cattaneo et al. "Izilinganiso Eziphelele Ze-Macrophage Migration Inhibitory Factor kanye ne-Interleukin-1-β mRNA Levels Predict Predict Treatment Response in Depressed Patients", I-International Journal ye-Neuropsychopharmacology, May 2016.