The I-D-dimers zivela ekuwohlokeni kwe-fibrin, iphrotheni ehilelekile ekujiyiseni kwegazi.

Uma amahlule egazi, isibonelo, uma kwenzeka elimele, ezinye zezakhi zalo zinamathelana, ikakhulukazi ngosizo lwe- i-fibrin.

Uma igazi lingahluleki ngokwanele, kungabangela ukopha okuzenzakalelayo (ukopha). Ngokuphambene nalokho, uma kudlulele, kungahlotshaniswa nokwakheka kwe amahlule igazi okungase kube nemiphumela eyingozi (i-deep vein thrombosis, i-pulmonary embolism). Kulokhu, kubekwa umshini wokuvikela ukuze ululaze i-fibrin eyeqile futhi yehlise ibe yizicucu, ezinye zazo ama-D-dimers. Ngakho-ke ukuba khona kwabo kungafakazela ukwakheka kwehlule legazi.

Udokotela uzonikeza ukuhlolwa kwe-D-dimer uma esola ukuthi kukhona amahlule egazi. Lokhu kungadala izinkinga ezinkulu, njenge:

• a i-vein thrombosis ejulile (ebizwa nangokuthi i-phlebitis ejulile, kuvela ekwakhekeni kwehlule kunethiwekhi ye-venous yezitho ezingezansi)

• i-pulmonary embolism (ukuba khona kwehlule ngaphandle komthambo wamaphaphu)

• noma unhlangothi

Umthamo we-D-dimers wenziwa isampula yegazi le-venous, ngokuvamile eyenziwa ezingeni lokugoqa kwendololwane. Zivame ukutholwa ngezindlela ze-immunological (ukusetshenziswa kwamasosha omzimba).

Akukho ukulungiselela okukhethekile okudingekayo.

Ukuhlushwa kwe-D-dimer egazini kuvamise ukuba ngaphansi kuka-500 µg/l (ama-micrograms ilitha).

Ukuhlolwa kwe-D-dimer kunevelu yokubikezela engalungile ephezulu. Ngamanye amazwi, umphumela ovamile uvumela ukukhishwa kokuxilongwa kwe-vein thrombosis ejulile kanye ne-pulmonary embolism. Ngakolunye uhlangothi, uma izinga le-D-dimer litholakala liphezulu, kukhona ukusola kokuba khona kwehlule elibonisa ukuthi kungenzeka ukuthi i-thrombosis ejulile ye-vein thrombosis noma i-pulmonary embolism. Lo mphumela kufanele uqinisekiswe ezinye izivivinyo (ikakhulukazi ngokuthwebula): ngakho-ke ukuhlaziya kufanele kuhunyushwe ngokuqapha.

Kukhona ngempela izimo zokukhuphuka kwezinga le-D-dimers elingahlobene nokuba khona kwe-deep vein thrombosis kanye ne-pulmonary embolism. Ake sicaphune:

• ukukhulelwa

• isifo sesibindi

• ukulahleka kwegazi

• ukukhuphuka kwe-hematoma,
• ukuhlinzwa kwakamuva

• isifo sokuvuvukala (njenge-rheumatoid arthritis)

• noma ukuba mdala (ngaphezu kweminyaka engama-80)

Qaphela ukuthi ukunqunywa kwama-D-dimers kuyinqubo yakamuva kakhulu (kusukela ekupheleni kweminyaka yama-90s), nokuthi amazinga aseyisihloko sokubuzwa imibuzo. Kangangoba eFrance, izinga lisungulwa njengelifanele libe ngaphansi kuka-500 µg/l, kanti e-United States lo mngcele wehliswa ube ngu-250 µg/l.