Thayipha isifo sikashukela sokuqala, esasibizwa ngaphambili isifo sikashukela esincike ku-insulin, ivame ukuvela ebuntwaneni noma ebusheni. Kuvame ukumenyezelwa ukoma okukhulu nokulahleka kwesisindo okusheshayo.

Imayelana ne- isifo se-autoimmune : kungenxa yokwehliswa kwamangqamuzana omzimba, aphambana nomzimba uqobo futhi abhubhise ikakhulukazi amaseli amanyikwe okuthiwa ama-beta cells (aqoqene ndawonye eziqhingini zaseLangherans).

Kodwa-ke, lawa maseli anomsebenzi obalulekile: akhipha i-insulin, ihomoni evumela ushukela (ushukela) ukuthi angene kumaseli omzimba futhi agcinwe futhi asetshenziswe lapho. Ngaphandle kwe-insulin, i-glucose ihlala egazini futhi idale i- "hyperglycemia", engaba nemiphumela emibi kakhulu yesikhathi esifushane neyesikhathi eside.

Ukwelashwa okuwukuphela kohlobo lwesifo sikashukela sohlobo 1 ngakho-ke umjovo we-insulin, ohlose ukunxephezela ukubhujiswa kwamaseli e-beta. Le mijovo ye-insulin ibizwa nangokuthi insulini.