Juni 4, 2010 - Ukusetshenziswa kwama-statins - umndeni wezidakamizwa ukwehlisa amazinga we-cholesterol egazini - kungadala imiphumela emibi eminingi ethinta amehlo, isibindi, izinso nemisipha.

Lokhu kukhonjiswa ngabaphenyi baseBrithani abahlaziya amarekhodi eziguli ezingaphezu kwezigidi ezi-2, i-16% yazo eyayiphethwe noma eyayivele yelashwa ngama-statins.

Ngokwedatha eqoqiwe, kubo bonke abasebenzisi abayi-10, ukuthatha ama-statin ngaphezu kweminyaka engu-000 kuvimbela amacala ama-5 esifo senhliziyo, kanye nama-271 inani lamacala omdlavuza wokuqopha.

Kodwa-ke, kubuye kubangele amanye amacala angama-307 we-cataract, amacala angama-74 okukhubazeka kwesibindi, amacala angama-39 we-myopathy kanye namacala angama-23 angeziwe ngamacala alinganiselayo noma abucayi okwehluleka kwezinso, futhi kubo bonke abasebenzisi abayi-10 bomuthi eminyakeni engaphezu kwengu-000.

Le miphumela emibi ivele kaningi emadodeni nakwabesifazane, ngaphandle kwe-myopathy - noma ukwehla kwemisipha - okuthinte cishe amadoda aphindwe kabili kunabesifazane.

Futhi uma le miphumela emibi yenzeka kuyo yonke iminyaka engu-5 lapho iziguli zalandelwa khona, ikakhulukazi ngesikhathi se-1^re unyaka wokwelashwa babevame kakhulu.

Le mininingwane isebenza kuzo zonke izinhlobo zezimila ezisetshenziswe ocwaningweni, okungukuthi i-simvastatin (enqunyelwe abangaphezu kuka-70% wababambiqhaza), i-atorvastatin (22%), i-pravastatin (3,6%), i-rosuvastatin (1,9%) ne-fluvastatin (1,4 , XNUMX%).

Kodwa-ke, i-fluvastatin idale izinkinga zesibindi eziningi uma kuqhathaniswa nezinye izigaba zama-statins.

Ngokusho kwabaphenyi, lolu cwaningo lungolunye lwabambalwa ukukala ubukhulu bemiphumela emibi yokuthatha ama-statins - iningi liqhathanisa umphumela walokhu ekwehliseni ubungozi benhliziyo nemithambo yegazi kwi-placebo.

Futhi, bakholelwa ukuthi izinkinga ezibonwayo akumele zifihle ukwehla okungama-24% ezimweni zezifo zenhliziyo ezithathwa yimithi, ngaphakathi kohlaka lolu cwaningo.

Ukulalela iziguli ngaphezulu

Ngokubheka imiphumela engezansi ebhalwe kulolu cwaningo, abacwaningi bancoma ukuthi odokotela balandele iziguli zabo eduze kakhulu ukuthola ngokushesha imiphumela emibi engahle yenzeke, ukulungisa noma ukumisa imithi yabo, uma kunesidingo.

Lokhu futhi kungumbono wesazi senhliziyo uPaul Poirier, umqondisi wohlelo lokuvimbela nokuvuselela inhliziyo e-Institut de cardiologie et de pneumologie de Québec.

"Lolu cwaningo lusinikeza izibalo zangempela ngokutholakala kwemiphumela emibi, futhi zibucayi," esho. Ngaphezu kwalokho, emtholampilo, lapho isiguli eselashwa ngama-statins sinenkinga yokuwohloka kwemisipha noma yesibindi, umuthi uyamiswa. "

Ingozi ephezulu yokuhlushwa ngulwelwesi iyamangaza uPaul Poirier. "Lolu lwazi lusha futhi aluyona into encane ngoba luthinta abantu asebekhulile asebevele begula, okukhona nengozi yokwengeza enye inkinga," kuqhuba yena.

Ngokusho kukadokotela wenhliziyo, imiphumela futhi iyisixwayiso emazweni ahlasela umqondo wokwenza ama-statin atholakale ngaphandle kwencwadi kadokotela.

"Kusobala ukuthi ukusetshenziswa kwama-statin kudinga ukuqashwa futhi kudinga ukuthi iziguli zaziswe ngokwanele ngemiphumela emibi engaba khona," kunezela udokotela wenhliziyo.

Kepha ngaphezu kwalokho, isifundo sase-UK sisebenza njengesikhumbuzo kodokotela abaphatha iziguli zabo ngama-statins.

“I-statin yisidakamizwa esinezingozi futhi kufanele sizilandele kakhulu iziguli. Ngaphezu kwakho konke, kufanele silalele futhi sikholwe isiguli esikhononda ngezimpawu, noma ngabe lezi zingabhalwanga ezincwadini zesayensi: isiguli asisona isibalo noma isilinganiso futhi kufanele siphathwe ngendlela eyingqayizivele ”, kuphetha uD.^r Isihlahla sepheya.

UMartin LaSalle - PasseportSanté.net

1.Hippisley-Cox J, et al, Imiphumela engahlosiwe yama-statins kwabesilisa nabesifazane eNgilandi naseWales: isifundo seqembu labantu esivela kubantu besebenzisa i-QResearch database, I-British Medical Journal, ishicilelwe ku-inthanethi ngomhla ka-20 Meyi 2010 ,; 340: c2197.

2. URosenberg H, Allard D, Prudence bopha: ukusetshenziswa kwama-statins kwabesifazane, Isenzo sokuvikela impilo yabesifazane, ngoJuni 2007.