I-Rett syndrome iyi- isifo sofuzo esingandile lokho kuphazamisa ukukhula nokuvuthwa kobuchopho. Iziveza ku izingane ezisacathula, cishe phakathi amantombazane.

Ingane ene-Rett syndrome ibonisa ukukhula okuvamile ekuqaleni kwempilo. Izimpawu zokuqala zivela phakathi Izinyanga ezingu-6 nezingu-18. Izingane ezinalesi sifo kancane kancane zinezinkinga ukunyakaza, ukuxhumana futhi ukukhulumisana ezithinta ikhono labo lokukhuluma, ukuhamba nokusebenzisa izandla zabo. Bese sikhuluma nge-polyhandicap.

Isigaba esisha se-Pervasive Developmental Disorders (PDD).

Nakuba i-Rett syndrome iyi-a isifo sofuzo, iyingxenye ye-Pervasive Developmental Disorders (PDD). Kuhlelo olulandelayo (oluzayo luka-2013) lwe-Diagnostic and Statistical Manual of Mental Disorders (DSM-V), i-American Psychiatric Association (APA) iphakamisa ukuhlukaniswa okusha kwe-PDD. Izinhlobo ezahlukene ze-autism zizohlanganiswa zibe yisigaba esisodwa esibizwa ngokuthi "Autism Spectrum Disorders". Ngakho-ke i-Rett syndrome izobhekwa njengesifo sofuzo esingavamile esihluke ngokuphelele.