umzimba syndrome - lokhu kuyinhlanganisela yama-hormonal kanye ne-metabolic pathologies, njengalokhu: ukukhuluphala ohlotsheni lwe-abdominal-visceral, ukuphazamiseka kwe-carbohydrate kanye ne-lipid metabolism, umfutho wegazi ophakeme we-arterial, ukuphazamiseka kokuphefumula phakathi nokulala ebusuku. Zonke lezi zifo zihlobene eduze komunye nomunye, futhi yinhlanganisela yazo enquma ubukhona be-metabolic syndrome kubantu. Le nkimbinkimbi ye-pathologies ibeka usongo empilweni yomuntu, ngakho ochwepheshe bayibiza ngokuthi i-quartet ebulalayo.
Lesi sifo sisabalele phakathi kwabantu abadala, kangangokuthi i-metabolic syndrome ingaqhathaniswa nobhubhane. Ngokwemithombo ehlukahlukene, i-20-30% yabantu abaneminyaka yobudala isukela eminyakeni engama-20 kuye kwengama-49 bayahlushwa. Kuleli banga lobudala, i-metabolic syndrome ivame ukutholakala emadodeni. Ngemuva kweminyaka engama-50, inani leziguli phakathi kwabesilisa nabesifazane liyalingana. Ngesikhathi esifanayo, kunobufakazi bokuthi abantu abanokukhuluphala ngokweqile baba ngo-10% ngaphezulu njalo eminyakeni eyi-10.
Lesi sifo sithinta kabi ukuqhubeka kwezifo zenhliziyo ezihlotshaniswa ne-atherosclerosis. I-syndrome iphinde ikhulise ingozi yokuba nezinkinga ze-coronary, okuholela ekufeni kweziguli. Uma umuntu ngaphezu kwalokhu ehlushwa ukukhuluphala, khona-ke amathuba okuthuthukisa i-arterial hypertension akhuphuka ngo-50% noma ngaphezulu.
Nakuba kungekho neyodwa ingqungquthela yaseRussia yephrofayili yokwelapha eqediwe ngaphandle kwengxoxo ye-metabolic syndrome, empeleni, iziguli zibhekene neqiniso lokuthi ngokuvamile azikutholi ukwelashwa okwanele kwesimo sazo. Ngokwemininingwane enikezwe i-State Research Center for Preventive Medicine, zingama-20% kuphela eziguli ezinikezwa ukunakekelwa okufanele kwe-antihypertensive, kuyilapho i-10% kuphela yeziguli ethola ukwelashwa okwanele kokwehlisa i-lipid.
Izinkinga ze-metabolic syndrome
Izimbangela eziyinhloko ze-metabolic syndrome zibhekwa njengokuthambekela kwesiguli ukumelana ne-insulin, ukudla kakhulu amafutha, nokuntuleka kokuzivocavoca umzimba.
Indima eyinhloko ekuthuthukisweni kwe-syndrome ingeyokumelana ne-insulin. Le hormone emzimbeni womuntu inesibopho semisebenzi eminingi ebalulekile, kodwa inhloso yayo eyisisekelo ukubopha ama-receptors azwelayo kuwo, akhona kulwelwesi lweseli ngalinye. Ngemuva kokuxhumana okwanele, inqubo yokuhambisa i-glucose engqamuzaneni iqala ukusebenza. I-insulin iyadingeka ukuze uvule lawa “masango okungena” eglucose. Kodwa-ke, lapho ama-receptors ehlala engayizwa i-insulin, i-glucose ayikwazi ukungena engqamuzaneni futhi inqwabelane egazini. I-insulin ngokwayo nayo inqwabelana egazini.
Ngakho-ke, izimbangela zokuthuthukiswa kwe-metabolic syndrome yilezi:
isisekelo sokumelana ne-insulin
Abanye abantu banalokhu kuthambekela kusukela bezalwa.
Ukuguqulwa kofuzo ku-chromosome 19 kuholela ezinkingeni ezilandelayo:
Amaseli ngeke abe nama-receptor anele azwela ku-insulin;
Kungase kube nama-receptors anele, kodwa awanakho ukuzwela kwe-insulin, okuholela ekutheni i-glucose nokudla kufakwe kuzicubu ze-adipose;
Amasosha omzimba womuntu angakhiqiza amasosha omzimba avimba ama-insulin-sensitive receptors;
I-insulin engavamile izokhiqizwa ama-pancreas ngokumelene nesizinda sokuncipha kwe-apparatus yesitho esibhekele ukukhiqizwa kweprotheyini ye-beta.
Kukhona cishe ukuguqulwa kofuzo okungama-50 okungaholela ekwandeni kwe-insulin. Ososayensi banombono wokuthi ukuzwela kwe-insulin yomuntu kuye kwaba phansi ngenxa yokuziphendukela kwemvelo, okwenza umzimba wakhe ukwazi ukubekezelela ngokuphepha indlala yesikhashana. Kuyaziwa ukuthi abantu basendulo babevame ukuswelakala kokudla. Ezweni lanamuhla, yonke into isishintshe kakhulu. Njengomphumela wokudla ngokweqile okunothe ngamafutha nama-kilocalories, amafutha e-visceral ayanqwabelana futhi kuthuthuke i-metabolic syndrome. Phela, umuntu wanamuhla, njengomthetho, akatholi ukuntuleka kokudla, futhi udla ikakhulukazi ukudla okunamafutha.
[Ividiyo] UDkt. Berg – Qapha i-insulin ye-Metabolic Syndrome. Kungani ibaluleke kangaka?