Le Isifo seGougerot-Sjögren (biza i-sjeu-greunne), okuyingxenye ye-syndromes eyomile, yisimo esingapheli semvelaphi ye-autoimmune, okungukuthi exhunywe ekuphenduleni kwamasosha omzimba ngokumelene nezakhi ezithile zomzimba, kulokhu izindlala ze-exocrine, ezikhipha uketshezi emzimbeni. isikhumba noma ulwelwesi lwamafinyila.

Ukutholwa kwayo kuqale ngo-1933, nguD^r Henrik Sjögren, udokotela wamehlo waseSweden.

Ukubonakaliswa kwayo kuhlotshaniswa nokungenwa kwezindlala ezithile ngama-lymphocyte okubangela ukwehla kwezimfihlo zazo. Izindlala zamathe zomlomo kanye nezindlala ze-lacrimal yizo ezivame ukuthinteka, ezibhekene “ne-dry syndrome”. Singakwazi futhi ukubona ukwehla komjuluko, i-sebum kodwa futhi nokungena kanye nokuvuvukala kwezinye izitho ezifana namaphaphu, izinso, amalunga noma imikhumbi emincane.

I-Gougerot-Sjögren syndrome yisifo esingajwayelekile esithinta umuntu oyedwa kwabayi-10. Abesifazane bathinteka ngokuphindwe ka-000 kunabesilisa. Ngokuvamile kwenzeka phakathi neminyaka eyi-10 kodwa kungenzeka ngaphambi kwesikhathi phakathi kweminyaka engama-50 nengama-20. 

izinhlobo

Lesi sifo singazibonakalisa ngezindlela ezimbili:

• Okuyinhloko. I-syndrome ibonakala yodwa. Kunjalo isikhathi esingu-1 kwabangu-2. Cishe u-93% walabo abathintekile bakhona abesifazane, futhi izimpawu ngokuvamile zivela cishe eminyakeni engu-50;
• Secondary. I-syndrome ihlotshaniswa nesinye isifo se-autoimmune, esivame kakhulu isifo samathambo.

Izimbangela

Imbangela ye- Isifo seGougerot-Sjögren akwaziwa. Kodwa-ke, lesi sifo sibangelwa ukusabela kwe-autoimmune. Isizathu sokuthi kungani izivikeli mzimba womzimba ufika ekungasebenzi kahle futhi uhlasele izicubu zawo kusenebulous. Kusacwaningwa ama-hypotheses amaningana. Ngokusho kwabacwaningi, kungenzeka ukuthi ukuqala kwalesi sifo kudinga kokubili ukuthambekela kofuzo nokufika kwe- bangela izici (ukutheleleka ngegciwane, izinguquko ze-hormonal, ukucindezeleka, njll.).

The izimpawu

Ezimweni ezingu-2/3 ukubonakaliswa okuhlotshaniswa nokubandakanyeka kwezindlala ze-exocrine kuhlotshaniswa nokubandakanyeka kwezinye izitho (lokhu kubizwa ngokuthi isifo se-systemic)

Amehlo omile kanye nomlomo ngokuvamile kuqala ukwenzeka. Kodwa-ke, zivela kamuva kubantu asebevele benesifo samathambo. 

Emehlweni, ukoma kungabangela ukuzwa okuvuthayo noma ukulunywa. Amajwabu amehlo avame ukunamathelana ekuseni, futhi amehlo azwela kakhulu ekukhanyeni.

Umlomo owomile wenza ukukhuluma, ukuhlafuna nokugwinya kube nzima kakhulu. 

Singabuye sibone ukukhwehlela okomile okuqhubekayo, ubuhlungu bamalunga, ubuhlungu bemisipha, ukukhathala

I-sicca syndrome ingaba yinkimbinkimbi ezingeni le-ocular nge-blepharitis noma i-keratitis futhi ezingeni lomlomo ngokulimala kwezinsini, imigodi, ukuhamba kwamazinyo, izilonda ze-canker, izifo zesibili zomlomo ikakhulukazi yi-mycoses. Umuntu angabona i-hypertrophy yezindlala ze-parotid, eyesikhashana noma cha.

Ukubonakaliswa okwengeziwe kwezindlala kuthinta amalunga (eyodwa koku-2), i-Raynaud's syndrome (iminwe iba mhlophe uma isabela emakhazeni). Okunye ukuhlasela kubi kakhulu kodwa akuvamile, ezingeni lamaphaphu, izinso, esikhumbeni noma eliseceleni kwemizwa. 

Ukukhathala kuvame kakhulu, futhi kuhambisana nobuhlungu obusakazekile.

kwesifo

Ukuxilonga kunzima ngoba umuntu akanazo zonke izimpawu futhi lezi zingase zihlobane nezinye izimo noma ukuphuza imithi.

Ukuhlolwa okuhlukahlukene kubalulekile: ukucinga amasosha omzimba egazini (anti-SS-A, anti-SS-B antibodies), ukuhlolwa kokukhiqizwa kwezindlala ze-lacrimal kusetshenziswa iphepha lokuhlunga (ukuhlolwa kwe-Schirmer), ukubhekwa kolwelwesi oluncane. okuvala iso ngokungcolisa i-rose bengal kanye nokuhlolwa kwamathe ukuhlola ukoma komlomo nokuboniswa kwamaqhuqhuva e-lymphocytic ku-biopsy yamathe; okwenziwa ezindlaleni zamathe omlomo, lesi senzo asinalo ulaka kakhulu futhi asibuhlungu. Ukuxilongwa kusekelwe ekuhlanganisweni kwenani lalezi zimpawu zomtholampilo nezebhayoloji. 

Udokotela angase futhi aphakamise ukuthi kuhlolwe ezinye izindawo zesifo noma amanye ama-autoimmune pathologies.

Ngesikhathi sokuxilongwa, udokotela ubuza isiguli ngesimo sakhe sempilo jikelele, izinhlobo zemithi ayiphuzayo, futhi mayelana nokudla kanye nenani lamanzi nolunye uketshezi olusetshenziswa nsuku zonke.