I-Aglan 15 - izinkomba, ukuphikisana, umthamo, imiphumela emibi

Okuqukethwe okuqinisekisiwe

I-Aglan 15, isithako esisebenzayo esiyi-meloxicam, ingeqembu lezidakamizwa ezingezona ukuvuvukala (ama-NSAID). Iphinde ibe nomphumela we-analgesic kanye ne-antipyretic, futhi iyatholakala ngencwadi kadokotela.

I-Aglan 15 - yini lesi sidakamizwa?

I-Aglan 15 iyisidakamizwa esingeyona i-steroidal eqeda ukuvuvukala. Ibuye ibe nomphumela we-analgesic kanye ne-antipyretic. Isithako sayo esisebenzayo yi-meloxicam, evimbela umsebenzi we-cyclooxygenase, ikakhulukazi i-cyclooxygenase-2 (COX-2) ne-cyclooxygenase-1 (COX-1).

I-Agalan 15 - inkomba yokusetshenziswa

Ukulungiswa kusetshenziselwa ikakhulukazi ukwelapha abantu asebekhulile, abantu abalimele, izisebenzi ze-blue collar kanye nabagijimi bangaphambili. Izinkomba zokusetshenziswa kwe-Agalan 15 yizifo ezinjengalezi:

1. i-rheumatoid arthritis yisifo esingelapheki. Kuhlanganisa izitho namalunga. Uma ukwelashwa kwe-rheumatoid arthritis kuyekwa kungelashwa, ukulimala kwamalunga futhi kwezinye izimo ngisho nokufa kuyophumela. Lesi sifo sibangelwa isifo semisipha, imisipha, amathambo kanye noqwanga. Lesi sifo sidalwa nayizakhi zofuzo, ukungasebenzi kwamasosha omzimba futhi kwesinye isikhathi nokucindezeleka okukhulu.
2. I-ankylosing spondylitis yisifo esingapheli sokuvuvukala komgogodla, izimpawu zazo ziyi-kyphosis nokukhubazeka. Nokho, lesi simo singase sithinte inqulu, ihlombe, amehlo, inhliziyo namaphaphu. Mhlawumbe imbangela yalesi sifo izifo zofuzo, i-immunological, imvelo kanye ne-bacterial. Izimpawu zokuqala zalesi sifo ubuhlungu obuphansi emuva obuphumela ezinqeni.
3. I-osteoarthritis ingenye yezifo ezivame kakhulu ohlelweni lwe-locomotor. Kubangelwa ukuphazamiseka kwe-articular cartilage - kokubili ngokwekhwalithi nobuningi. Izimpawu zalesi sifo ubuhlungu nokuqina kwamalunga, okuhlanekezela ama-contours awo futhi kunciphise ukuhamba kwawo. Umphumela wako ukukhubazeka kanye nokuwohloka kwezinga lempilo.

I-Aglan 15 - isenzo

Into esebenzayo ye-Aglan 15, njengezinye izidakamizwa ezingezona ukuvuvukala, ivimbela i-biosynthesis kanye ne-prostaglandins. Ukumuncwa kwayo okuphelele kwenzeka ngemuva komjovo we-intramuscular. I-Meloxicam ibophezela kumaprotheni e-plasma bese ingena ku-synovial fluid, lapho ifinyelela ekugxilweni cishe kwesigamu se-plasma.

Isitho esinomthwalo omkhulu wokugaya into esebenzayo yomuthi isibindi. I-Melkosicam ikhishwa kokubili esibindini nasendle, kokubili ngenani elifanayo. Imuncwa kahle emgudwini wokugaya ukudla. Ngemuva kokuphathwa ngomlomo, ukugxila okuphezulu egazini kutholakala kungakapheli amahora angama-5-6 ngemuva kokuphathwa, kanye nesimo esiqinile phakathi nezinsuku ezingama-3-5 zokusetshenziswa.

I-Aglan 15 - ama-contraindication

I-Aglan 15 akufanele ithathwe abantu abane:

1. i-hypersensitivity ku-meloxicam,
2. i-hypersensitivity ezintweni ezifana ne-meloxicam,
3. ukuhlasela kwe-asthma
4. ama-polyps ekhaleni,
5. i-angioedema,
6. izilonda ngemuva kokuthatha ama-NSAID,
7. izinhlungu ngemuva kokuthatha i-acetylsalicylic acid,
8. izifo ze-hemostatic,
9. ukuthatha ama-anticoagulants,
10. ukopha emathunjini
11. ku-trimester yesithathu yokukhulelwa.

Ukuphikisana nokuthatha i-Aglan 15 nakho kukhona:

1. isifo se-peptic ulcer - into esebenzayo yokulungiswa akufanele isetshenziswe abantu abanesifo se-peptic esisebenzayo noma esiphindaphindiwe. Ukwehluleka ukwenza kanjalo kungase kucasule ulwelwesi lwesisu noma lwe-duodenum, kubangele ubuhlungu obuvuthayo esiswini obuphuma esifubeni kuye enkabeni. Ibangelwa ukuthi i-asidi yesisu ihlangana nesilonda noma isilonda esiswini. Ukusetshenziswa kwe-Aglan 15 kulokhu kungase kube nemiphumela emibi kakhulu empilweni.
2. Ukwehluleka okukhulu kwesibindi - kubonakaliswa ukuwohloka okungazelelwe kokusebenza kwesibindi. Kungenzeka ngenxa yokutheleleka nge-HBV, HAV, HCV, ngenxa yobuthi bezidakamizwa kanye nokusabela komzimba ku-hepatic vein thrombosis noma izifo zesistimu. Ukwehluleka kwesibindi akuxilongwa ngokushesha njengoba kuvame ukungabi nabuhlungu.
3. Ukwehluleka okukhulu kwezinso ezigulini ezingayitholi i-dialysis - uphawu lwalesi sifo ukukhubazeka okungazelelwe kokusebenza kwesibindi. Bese kuba nokwanda kokuhlushwa kwe-creatinine egazini. Isiguli siqala ukukhipha umchamo omncane, sihlanza, sihudo, siphelelwe amanzi emzimbeni futhi siyasha. Ukwehluleka kwezinso okukhulu kuvame ukwenzeka ngenxa yezinhlekelele ezihlukahlukene, isib. izimpi, ukuzamazama komhlaba. Izimbangela zayo zingase zibe izifo ezine-nephritis. Ngaphezu kwalokho, kungase futhi kubangelwe izidakamizwa non-steroidal eqeda ukuvuvukala kanye namalungiselelo herbal izinga ezingabazisayo.
4. Ukuhluleka kwenhliziyo okungalawuleki kakhulu yisimo lapho inhliziyo iphampa igazi elincane kakhulu ezithweni ezithile. Ngenxa yalokho, izitho zomzimba ziphelelwa umoya-mpilo futhi azikwazi ukusebenza kahle. Lesi simo senzeka ngokushesha. Izimbangela zayo ngokuvamile ziyizifo ezihlukahlukene zesimiso senhliziyo, ngokuvamile isifo segazi se-ischemic.

I-Aglan 15 - umthamo

Umuthi uphathwa njengomjovo. Umthamo onconyiwe ngu-7,5-15 mg / ngosuku. Ezifweni ezifana ne-rheumatoid arthritis noma i-ankylosing spondylitis, umthamo onconywayo ngu-15 mg / ngosuku. Imijovo ifakwa ekujuleni komsipha engxenyeni engaphezulu engaphandle yesinqe. Imijovo isetshenziswa ngokushintshana - okungukuthi kanye kwesokunxele kanye esinqeni sokudla. Nge-sciatica, umuthi ungandisa ubuhlungu ngesikhathi semithamo yokuqala.

Umthamo womuthi nawo uncike eminyakeni yesiguli. Amaqembu akhethekile eziguli angabantu abadala, abantu abanenkinga yokungasebenzi kahle kwezinso, abantu abanesifo se-hepatic kanye nezingane. Ngokwezincomo zomkhiqizi, umthamo womuthi onganikezwa abadala ngu-7,5 mg; iziguli okungenzeka zibe nemiphumela engemihle zinganikezwa ama-7,5 mg ngosuku.

Umthamo weziguli ze-dialysis ezinokukhubazeka okukhulu kwezinso akufanele udlule ingxenye ye-ampoule. Ngaphezu kwalokho, iziguli ezinokwehluleka okukhulu kwezinso akufanele zinikezwe ukulungiswa. Ngokuphambene, lapho ukwehluleka kwezinso kulinganiselwe, umthamo akufanele wehliswe. Isinqumo ngosayizi womthamo kanye nezinguquko ezingaba khona enanini laso kufanele kuboniswane nochwepheshe ofanele. Ngaphezu kwalokho, azikho izifundo ezingaqinisekisa ukuphepha nokusebenza ngempumelelo kokuphatha i-Aglan ezinganeni eziyi-15 kanye nentsha efika eminyakeni eyi-18.

I-Aglan 15 - imiphumela emibi

I-Aglan 15 ingase ibangele ukusabela kwesikhumba. Iziguli ezilashwa nge-meloxicam zingase zibe ne-Stevens-Johnson syndrome. Kubuye kube nemibiko ye-epidermal necrolysis. Ngakho-ke, ngaphambi kokuqala ukwelashwa ngokulungiselela, isiguli kufanele saziswe ukuthi ukusabela okunjalo kungenzeka. Kuyafaneleka ukwengeza ukuthi amathuba okuba ne-Stevens-Johnson syndrome kanye nokuhlukaniswa kwe-epidermal makhulu phakathi namasonto okuqala okwelashwa.

I-Aglan 15, njengamanye ama-NSAID, ingakhuphula i-serum transaminosis. Ngaphezu kwalokho, ingaphinda iguqule izimpawu zokusebenza kwesibindi. Lapho izinguquko ezibangelwa yikho zifakazela ukuthi zihlala isikhathi eside, khona-ke umuthi kufanele umiswe futhi kwenziwe ukuhlolwa okufanele. Imiphumela engemihle ingaba yinkinga ikakhulukazi kubantu abanamasosha omzimba abuthaka kanye nabantu abanomzimba okhanyayo.

I-Aglan 15 - izinyathelo zokuphepha

Ukusetshenziswa kwama-NSAID kwandisa ingozi yokopha emathunjini, isifo sezilonda noma ukubhobozwa - uma umthamo womuthi uphezulu, amathuba okuthi ukopha ayanda. Abantu abakuleli qembu labasengozini kufanele bahlale bebonana nodokotela wabo mayelana nanoma yiziphi izinqumo eziphathelene nokusetshenziswa komuthi. Leli qembu leziguli livame ukutuswa ukuthi lithathe umthamo ophansi kakhulu we-Aglan 15.

Uma noma yimiphi imiphumela emibi ivela ngesikhathi sokwelashwa, thintana nodokotela ngokushesha. Ukuqapha kufanele kusetshenziswe ezigulini ezithatha imithi ehambisanayo ezingase zandise ingozi yokuba nesilonda noma ukopha. i-corticosteroids yomlomo, ama-anticoagulants, ama-serotonin reuptake inhibitors akhethiwe noma izidakamizwa ze-antiplatelet.

Abantu abane-arterial hypertension kufanele bathole ukunakekelwa okukhethekile kwezokwelapha ngesikhathi sokwelashwa ngomuthi. Kukhona ingozi yokuthi ukuthatha ama-NSAID athile kungase kwandise ingozi yokuhlaselwa yinhliziyo noma unhlangothi, ikakhulukazi kubasebenzisi besikhathi eside. Abantu abaphethwe izifo ezifana:

1. Isifo senhliziyo (i-coronary artery disease) - lesi yisimo lapho inhliziyo inganikezwa ngokwanele umoya-mpilo. Isizathu siwukuncipha kwemithambo yenhliziyo, okuyiyona enesibopho sokuhlinzekwa kwezakhamzimba emisipha yenhliziyo. I-coronary artery isifo ngokuvamile i-atherosclerotic. Yisifo senhliziyo esivame kakhulu emazweni asethuthuke kakhulu.
2. umfutho wegazi ophakeme ongalawuleki - imbangela yalesi sifo ukucindezela okukhulu kwegazi ezindongeni zemithambo. Ngenxa yalokho, kukhona umonakalo ezitsheni futhi ngaleyo ndlela nesifo senhliziyo. Inani lomfutho wegazi lincike esilinganisweni segazi elimpontshelwa emithanjeni kanye nokumelana nemithambo ye-peripheral. Lesi sifo singase singabonakali isikhathi eside, kanti ezinye zazo zihlanganisa ikhanda elibuhlungu, isiyezi kanye nokopha.
3. isifo se-peripheral arterial - isimo esibangela ukuthi imithambo yakho ibe mincane futhi ivimbe, okuholela ekunciphiseni ukugeleza kwegazi. Kubangelwa ukunqwabelana koqweqwe lwamafutha emithanjeni yakho. Izimpawu zalesi sifo zihlanganisa ukukhathala nokuba buthakathaka emilenzeni, ubuhlungu bemilenze, ukushoshozela ezinyaweni, ukuba ndikindiki ezandleni nasezinyaweni, isikhumba esibandayo kanye nokushintsha kombala wesikhumba.
4. isifo se-cerebrovascular - yiqembu lezifo uphawu lwazo luphazamiseka ukugeleza kwegazi ezingxenyeni ezithile zobuchopho. Lezi zifo, isibonelo, isifo sohlangothi, ukopha kwe-subarachnoid, i-aneurysms yobuchopho, i-atherosclerosis ye-cerebral engapheli, i-cerebral thrombosis, i-cerebral embolism. Izifo zingabulala. Izici ezinomthelela ekwakhekeni kwazo yilezi: umfutho wegazi ophakeme, i-cholesterol ephezulu kanye nokukhuluphala ngokweqile.

I-Aglan 15 - ukusebenzisana nezinye izidakamizwa

Ukusebenzisa kanyekanye i-Aglan 15 namanye ama-NSAID kungase kube nomthelela ekwandeni kwezilonda emathunjini nokopha. Akukhuthazwa futhi ukuthatha izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala kanye nama-anticoagulants omlomo ngesikhathi esifanayo.

I-Aglan 15, njengamanye ama-NSAID, inganciphisa ukusebenza kwe-diuretics nezidakamizwa ze-antihypertensive. Okusongela impilo, ikakhulukazi kubantu abadala kanye nabantu abanokukhubazeka kwezinso, ukusetshenziswa kanyekanye, isibonelo, ama-ACE inhibitors nama-ejenti avimbela i-cyclooxygenase. Iziguli ezithatha le mithi kufanele ikakhulukazi zihlale zinamanzi.

Ukusetshenziswa kanyekanye kwe-Aglan 15 nezidakamizwa ze-antihypertensive nakho kuyingozi. Njengomphumela, umuthi we-antihypertensive we-beta-adrenergic blocker awusebenzi kahle. Kwezinye izimo, ama-NSAID akhulisa i-nephrotoxicity ye-cyclosporine ngenxa yomphumela wawo ku-renal prostaglandins. Abantu abaphuza lesi sidakamizwa kufanele bahlale ngaphansi kweso lodokotela - lokhu kusebenza ikakhulukazi kwasebekhulile.