Ama-analogues angu-10 amahle kakhulu we-bisoprolol
I-Bisoprolol ivame ukunikezwa isifo senhliziyo, noma kunjalo, umuthi awutholakali njalo emakhemisi, futhi intengo yawo iphezulu kakhulu. Sikanye nodokotela wenhliziyo, senze uhlu lwezinto ezingabizi nezisebenzayo esikhundleni seBisoprolol futhi saxoxa ngokuthi zithathwe kanjani futhi nini.

I-Bisoprolol iyingxenye yeqembu lama-beta-blockers akhethiwe futhi isetshenziswa ku-cardiology ye-coronary heart disease, ukwehluleka kwenhliziyo okungapheli. Ngokuvamile kunqunyelwe ukwelashwa kwe-arrhythmias yenhliziyo kanye nomfutho wegazi ophakeme.1.

I-Bisoprolol inciphisa ingozi ye-myocardial infarction nokufa kwenhliziyo. Umuthi unciphisa ukusetshenziswa komoya-mpilo ngemisipha yenhliziyo, unweba izitsha ezondla inhliziyo, unciphisa imvamisa yokuhlaselwa kobuhlungu futhi ube nomthelela omuhle ekuqaguleni kwesifo.2.

Imiphumela emibi lapho uthatha i-bisoprolol ayivamile. Njengomthetho, zihlotshaniswa nohlelo lokusebenza olukhethwe ngokungalungile. Ngenxa yalokhu, isiguli singanciphisa kakhulu umfutho wegazi futhi sehlise ukushaya kwenhliziyo. Phakathi kweminye imiphumela emibi: isiyezi, ikhanda elibuhlungu, i-dyspepsia, ukuphazamiseka kwesitulo (ukuqunjelwa, isifo sohudo). Ukuvama kokuvela kwabo akudluli i-10%.

I-Bisoprolol inqunyelwe ukunakekelwa okukhulu ezigulini ezine-asthma ye-bronchial kanye ne-atherosclerosis yemithambo yemikhawulo engezansi. Ekwehlulekeni kwenhliziyo, umuthi kufanele uthathwe ngemithamo emincane - 1,25 mg kanye ngosuku.

Uhlu lwama-analogue aphezulu ayi-10 kanye nezindawo ezishibhile zeBisoprolol ngokwe-KP

1. Concor

I-Concor itholakala ngohlobo lwethebhulethi engu-5 no-10 mg futhi iqukethe i-bisoprolol njengesithako esisebenzayo. Umphumela oyinhloko womuthi uhlose ukunciphisa izinga lokushaya kwenhliziyo kokubili lapho uphumule futhi ngesikhathi sokuzivocavoca, kanye nokwelula imithambo yenhliziyo.

I-Concor ithathwa isikhathi esingu-1 ngosuku ekuseni, kungakhathaliseki ukuthi yikuphi ukudla. Isenzo somuthi sithatha amahora angama-24.

Ukungafani: ukuhluleka kwenhliziyo okubuhlungu nokungapheli, ukushaqeka kwe-cardiogenic, ukuvinjelwa kwe-sinoatrial, i-bradycardia eqinile kanye ne-arterial hypotension, izinhlobo ezinzima zesifuba somoya, iminyaka efika ku-18.

ukushintshwa okuphumelelayo kakhulu komuthi wokuqala, indlela yokusebenza efundiwe.
Uhlu olubanzi lwe-contraindication.

2. Niperten

I-Niperten itholakala ngendlela yethebhulethi engu-2,5-10 mg futhi iqukethe ne-bisoprolol ekubunjweni kwayo. Umphumela womuthi uzwakala kakhulu emahoreni angama-3-4 ngemuva kokumunca, kepha ukugxila egazini kuqhubeka amahora angama-24, okuqinisekisa umphumela omude wokwelapha. I-Niperten kufanele ithathwe kanye ngosuku ekuseni, kungakhathaliseki ukuthi udla ngani.

Ukungafani: ukwehluleka kwenhliziyo okunamandla, ukwehluleka kwenhliziyo okungapheli esigabeni sokubola, ukushaqeka kwe-cardiogenic, ukuwa, ukwehla okukhulu komfutho wegazi, izinhlobo ezinzima zesifuba somoya we-bronchial kanye ne-COPD emlandweni, ubudala obufika eminyakeni engu-18.

intengo ephansi uma iqhathaniswa ne-Concor, isebenza amahora angama-24.
akuwona umkhiqizo wangempela.

3. I-Bisogamma

I-Bisogamma nayo iqukethe i-bisoprolol futhi itholakala kumathebulethi angu-5 no-10 mg. Lona umuthi wansuku zonke - umphumela wawo wokwelapha uhlala amahora angu-24.

Qala ukwelashwa ngomthamo we-5 mg 1 isikhathi ngosuku. Khona-ke, uma kunesidingo, umthamo ukhuphuka ube ngu-10 mg 1 isikhathi ngosuku. Umthamo omkhulu ovunyelwe ngosuku ngu-20 mg. I-Bisogamma kufanele ithathwe ekuseni ngaphambi kokudla.  

Ukungafani: ukushaqeka (kuhlanganise ne-cardiogenic), i-pulmonary edema, ukwehluleka kwenhliziyo okunamandla, ukwehluleka kwenhliziyo okungapheli esigabeni sokudilizwa, i-bradycardia eqinile, i-arterial hypotension (ikakhulukazi nge-infarction ye-myocardial), izinhlobo ezinzima zesifuba somoya kanye nezinye izifo zokuphefumula umoya, ukudangala, ukukhula ngeminyaka. ukuya eminyakeni eyi-18.

intengo ethengekayo.
akusona isidakamizwa sokuqala, uhlu olukhulu lwe-contraindication.

4. I-Concor Core

I-Concor Cor iyi-analogue egcwele yomuthi i-Concor, kanye nokuthatha indawo ye-Bisoprolol ngempumelelo. Ukwakheka nakho kuqukethe into esebenzayo yegama elifanayo, futhi umehluko omkhulu usesilinganisweni. I-Concor Cor itholakala kuphela ngomthamo we-2,5 mg. Ngaphezu kwalokho, amaphilisi amhlophe, ngokungafani ne-Concor, enombala omnyama ngenxa yokugxila okuphezulu kwento esebenzayo.

Ukungafani: i-hypersensitivity ezingxenyeni zomuthi, ukwehluleka kwenhliziyo okubuhlungu nokungapheli, ukushaqeka kwe-cardiogenic, i-bradycardia eqinile kanye nomfutho wegazi ophakeme we-arterial, izinhlobo ezinzima zesifuba somoya, iminyaka efinyelela eminyakeni eyi-18.

amahora angama-24 asebenzayo.
ngenxa yomthamo, inqunyelwe kuphela ukwelashwa kokuhluleka kwenhliziyo okungapheli.

5. I-Coronal

Futhi futhi, umuthi oqukethe into esebenzayo i-bisoprolol. I-Coronal itholakala kumaphilisi angu-5 no-10 mg futhi isebenza amahora angu-24. Udinga ukuthatha ithebhulethi 1 isikhathi ngosuku ekuseni ngaphambi kokudla. Umthamo omkhulu wansuku zonke ngu-20 mg.

Ukungafani: ukushaqeka (kuhlanganise ne-cardiogenic), ukwehluleka kwenhliziyo okunamandla kanye nokungasebenzi kahle okungapheli, i-bradycardia enzima, i-cardiomegaly (ngaphandle kwezimpawu zokwehluleka kwenhliziyo), i-arterial hypotension (ikakhulukazi nge-infarction ye-myocardial), isifuba somoya nesifo samaphaphu esingamahlalakhona emlandweni, isikhathi sokuncelisa, iminyaka yobudala ukuya eminyakeni eyi-18.

intengo ethengekayo, umphumela wokwelapha uhlala amahora angama-24.
izinketho ezimbalwa zomthamo. Akusona isidakamizwa sokuqala.

6. I-Bisomor

Umuthi i-Bisomor uqukethe ne-bisoprolol futhi iyindawo engabizi kodwa esebenzayo yomuthi wokuqala onegama elifanayo. I-Bisomor itholakala kumaphilisi anomthamo we-2,5, 5 kanye ne-10 mg futhi isebenza amahora angama-24. Thatha umuthi kanye ngosuku ekuseni ngaphambi kokudla. Umthamo omkhulu ovunyelwe nsuku zonke ngu-1 mg.

Ukungafani: ukushaqeka (kuhlanganise ne-cardiogenic), ukwehluleka kwenhliziyo okunamandla kanye nokungasebenzi kahle okungapheli, i-bradycardia enzima, i-cardiomegaly (ngaphandle kwezimpawu zokwehluleka kwenhliziyo), i-arterial hypotension (ikakhulukazi nge-infarction ye-myocardial), isifuba somoya nesifo samaphaphu esingamahlalakhona emlandweni, isikhathi sokuncelisa, iminyaka yobudala ukuya eminyakeni eyi-18.

izinketho ezahlukene zemithamo, umphumela omenyezelwe amahora angama-24.
akusona isidakamizwa sokuqala, uhlu olubanzi lwe-contraindication.

7. Egilok

Umuthi i-Egilok awuthathi indawo elinganayo yeBisoprolol, njengoba iqukethe i-metoprolol njengesithako esisebenzayo. Isenzo esiyinhloko se-Egilok sihloselwe ukwehlisa umfutho wegazi nokushaya kwenhliziyo.

Umuthi ukhiqizwa amaphilisi ngomthamo we-25, 50 no-100 mg. Umphumela omkhulu ubonwa emahoreni angama-1-2 ngemuva kokuphathwa. Udinga ukuthatha amaphilisi izikhathi 2-3 ngosuku.

Ukungafani: ukwehluleka kwenhliziyo esigabeni sokubola, ukushaqeka kwe-cardiogenic, ukuphazamiseka okukhulu kokujikeleza kwe-peripheral, kufaka phakathi usongo lwe-gangrene, i-acute myocardial infarction, ukuncelisa ibele, iminyaka efika kweyi-18.

umphumela osheshayo wokwelapha. Ayisetshenziselwa ukwelapha i-angina pectoris kanye nomfutho wegazi ophakeme, kodwa futhi i-ventricular extrasystole ne-supraventricular tachycardia.
umphumela wesikhashana, kuyadingeka ukuthatha umuthi izikhathi ezi-2 ngosuku.

8. Betalok ZOC

Okunye ukushintshwa yiBisaprolol, equkethe i-metoprolol. I-Betaloc ZOK itholakala ngohlobo lwamaphilisi, futhi isenzo sayo esiyinhloko ukwehlisa umfutho wegazi. Umphumela omkhulu womuthi uzwakala emahoreni angama-3-4 ngemuva kokuwuthatha. I-Betaloc ZOK inesenzo eside, ngakho sithathwa kanye ngosuku.

Ukungafani: I-AV block II ne-III degree, ukwehluleka kwenhliziyo esigabeni sokubola, i-sinus bradycardia, ukushaqeka kwe-cardiogenic, i-arterial hypotension, okusolwa ukuthi i-acute myocardial infarction, ubudala obungaphansi kweminyaka engu-18.

uhlu olukhulu lwezinkomba zokusetshenziswa (i-angina pectoris, umfutho wegazi ophakeme, ukuhluleka kwenhliziyo, i-migraine prophylaxis), isebenza amahora angu-24.
imiphumela engemihle: bradycardia, ukukhathala, isiyezi.

9. I-SotaGEKSAL

I-SotaGEKSAL iqukethe i-sotalol futhi itholakala ngohlobo lwamaphilisi anomthamo ongu-80 no-160 mg. I-Sotalol, nakuba ingeye-beta-blockers, njenge-bisoprolol, nokho, isetshenziswa kakhulu njengesidakamizwa esinomphumela we-antiarrhythmic futhi inqunyelwe ukuvimbela i-atrial arrhythmias kanye nokugcinwa kwesigqi se-sinus. Kudingeka ukuthatha i-SotaGEKSAL izikhathi ezingu-2-3 ngosuku.

umphumela osheshayo wokwelapha.
kudinga ukuqapha isimo sesiguli ku-ECG. Imiphumela emibi engaba khona: ukwehla kwesilinganiso senhliziyo nomfutho wegazi, ukwanda kokuzwela ezingxenyeni zomuthi.

10. Abangenalo ithikithi

I-Nebilet iqukethe into esebenzayo i-nebivolol. Umuthi ukhiqizwa ngendlela yamaphilisi ngomthamo we-5 mg. Isenzo esiyinhloko se-Nebilet sihloselwe ukwehlisa umfutho wegazi ekuphumuleni nokuzikhandla ngokomzimba, kanye nangesikhathi sokucindezeleka. Umphumela omkhulu uvela kungakapheli amahora angama-1-2 ngemuva kokuthatha umuthi. Udinga ukuthatha i-Nebilet isikhathi esingu-1 ngosuku.

Ukungafani: ukwehluleka kwenhliziyo okunamandla, ukwehluleka kwenhliziyo okungapheli esigabeni sokubola, i-arterial hypotension eqinile, i-bradycardia, ukushaqeka kwe-cardiogenic, ukungasebenzi kahle kwesibindi, umlando we-bronchospasm kanye nesifuba somoya, ukucindezeleka, iminyaka engaphansi kwe-18.

ikhuthaza ukukhiqizwa kwe-nitric oxide, ngakho-ke ivikela futhi iqinise izindonga zemithambo yegazi, yehlisa ngokushesha umfutho wegazi.
imiphumela emibi engase ibe khona: ikhanda, isiyezi, isicanucanu.

Ungakhetha kanjani i-analogue ye-bisoprolol?

Zonke lezi zidakamizwa ezingenhla, ngokwezinga elithile noma kwelinye, ziyi-analogue ye-Bisoprolol. Zihluke ngobukhulu kanye nobude bomphumela wokwelapha, ukuncibilika emafutheni nasemanzini, kanye nemiphumela eyengeziwe kanye nemiphumela emibi.3. Udokotela kuphela ongakhetha i-analogue esebenzayo ye-bisoprolol, ngoba umuthi ngamunye unezici zawo zokusetshenziswa, futhi izinto ezisebenzayo azishintsheki. Isibonelo, awukwazi ukufaka esikhundleni sika-10 mg we-bisoprolol ngo-10 mg we-nebivolol - lokhu kungalimaza kakhulu impilo yakho.

Izibuyekezo odokotela mayelana analogue Bisoprolol

Odokotela benhliziyo abaningi batusa isidakamizwa i-Concor, esinciphisa ngempumelelo ukushaya kwenhliziyo futhi singabangeli imiphumela emibi. Kungcono ukukhetha umthamo womuthi, uqale ngomncane kakhulu, bese uwushiya isikhathi eside4.

Odokotela baphinde batusa ukusebenzisa i-Betalok ZOK. Umuthi wehlisa ngempumelelo umfutho wegazi futhi uthathwa isikhathi esingu-1 kuphela ngosuku.

Ngasikhathi sinye, ochwepheshe bagcizelela ukuthi naphezu kwenani elikhulu lama-analogues e-Bisoprolol, udokotela kuphela ongakhetha umuthi odingekayo.

Imibuzo nezimpendulo ezidumile

 Sixoxe ngezindaba ezibalulekile ezihlobene nama-analogues e-bisoprolol udokotela wesayensi yezokwelapha, udokotela wenhliziyo uTatyana Brodovskaya.

Yiziphi iziguli ezinconywe i-bisoprolol?

- Okokuqala, lezi yiziguli ezine-angina pectoris, ukuhluleka kwenhliziyo okungapheli. Kulokhu, sibona umphumela omuhle onamandla ekubikezelweni kokuvimbela ukufa, kanye nokuncipha kwemvamisa yezinkinga eziyingozi (isibonelo, i-myocardial infarction). Kodwa ekwelapheni i-arterial hypertension, leli klasi lezidakamizwa lidinga kancane namuhla, nakuba lifakwe ohlwini lwezinkomba ezibhalisiwe.

Kwenzekani uma uyeka ukusebenzisa iBisoprolol bese ushintshela ku-analogue?

- Into yokuqala ebalulekile okufanele uyinake ukuthi ama-beta-blockers awanconywa ukuthi akhanselwe kungazelelwe. Ukukhansela kufanele kwenzeke kancane kancane futhi ngaphansi kokuqondisa kodokotela.

Imiphumela emibi efana ne-bradycardia, ukuthuthukiswa kokuvinjelwa kwe-atrioventricular, ukunciphisa ingcindezi kuncike ngokuqondile kumthamo womuthi. Ngakho-ke, uma kuvela imiphumela emibi, ungaxoxa nodokotela wakho ngendaba yokunciphisa umthamo, futhi ungayiqedi ngokuphelele.

Ukukhethwa kwe-analogue nokushintshwa kwe-bisoprolol akukwazi ukuphathwa ngokuzimela. Udokotela kuphela ozocabangela zonke izici zesimo somtholampilo wesiguli: ukuba khona kwe-hypertrophy ye-ventricular kwesokunxele, i-dyslipidemia, isimo sesibindi nezinso, i-arrhythmias, bese ukhetha i-beta-blockers edingekayo.

  1. I-Shlyakhto EV Cardiology: umhlahlandlela kazwelonke. M., 2021. https://www.rosmedlib.ru/book/ISBN9785970460924.html
  2. izindinganiso zomtholampilo. I-Cardiology. EV Reznik, IG Nikitin. M., 2020. https://www.studentlibrary.ru/book/ISBN9785970458518.html
  3. Клинические рекомендации «Хроническая сердечная недостаточность у взрослых». 2018 – 2020. https://diseases.medelement.com/disease/%D1%85%D1%80%D0%BE%D0%BD%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F-%D1%81%D0%B5%D1%80%D0%B4%D0%B5%D1%87%D0%BD%D0%B0%D1%8F-%D0%BD%D0%B5%D0%B4%D0%BE%D1%81%D1%82%D0%B0%D1%82%D0%BE%D1%87%D0%BD%D0%BE%D1%81%D1%82%D1%8C-%D1%83-%D0%B2%D0%B7%D1%80%D0%BE%D1%81%D0%BB%D1%8B%D1%85-%D0%BA%D1%80-%D1%80%D1%84-2020/17131
  4. 2000-2022. UKUBHALISA IMITHI YE-RUSSIA® RLS https://www.rlsnet.ru/

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