I-Fecal elastase iyi-enzyme ekhiqizwa ama-pancreas edlala indima ekugayweni kokudla. Umthamo wayo wenza kube nokwenzeka ukuhlola ukusebenza kahle komsebenzi wamanyikwe ohambisana nokugaya.

I-pancreas iyisitho somzimba womuntu esinemisebenzi emibili:

• umsebenzi we-endocrine we-10% wamaseli: i-pancreas ikhiqiza i-insulin ne-glucagon, amahomoni amabili aphethe ukulawula izinga likashukela egazini. I-insulin yehlisa ushukela wegazi ngenkathi iglucagon iwunyusa. Lawa mahomoni amabili asiza ukugcina amazinga kashukela egazini elinganisela. Uma kunenkinga ngokukhishwa kwe-insulin, sikhuluma ngesifo sikashukela;
• umsebenzi we-exocrine ku-90% wamaseli: by Amaseli e-acinar, ama-pancreas akhiqiza ama-enzyme e-pancreatic, amaprotheni anendima ethile. Lawa ma-enzyme ayingxenye yejusi ye-pancreas futhi abalulekile ekugayeni ukudla okufanele. Ngokuchema kweziteshi ze-Wirsung ne-Santorini, amajusi e-pancreatic ashiya ama-pancreas azohlangana ne-bile emathunjini. Emgudwini wokugaya ukudla, lawa ma-enzyme abamba iqhaza ekugayweni kwamafutha, amaprotheni nama-carbohydrate ngokuwahlukanisa abe izakhi eziningi, ezimuncwa kalula ngumzimba.

I-Fecal elastase ingenye yama-enzyme akhiqizwa amanyikwe. Ikhiqizwa ngendlela ezinzile futhi engaguquki, okwenza kube inkomba enhle ye-pancreatic. Inhloso yokuhlolwa kwe-fecal elastase ukuhlola ukusebenza kahle komsebenzi we-exocrine we-pancreas. Inani lereferensi lingama-micrograms angu-200 igremu ngayinye yesitulo kubo bobabili abadala kanye nezingane (kusukela ngenyanga eyodwa ubudala). Leli nani lizinzile futhi liyahluka kancane ukusuka kolunye usuku kuye kolunye kumuntu ofanayo ngaphandle kwesifo sohudo esinzima esinciphisa izinga le-fecal elastase. Kulokhu, ukuhlaziywa kuzodingeka kuphindwe. Ukuhlola okulula ukukukwenza, okuvumela ukuthi kuthathelwe indawo ezinye izivivinyo ezinzima njengocwaningo lwe-steatorrhea.

Lokhu kuhlolwa kwenziwa ukuze kuhlolwe ukusebenza komsebenzi we-exocrine we-pancreas. Kungenziwa ngokwesibonelo uma kwenzeka izinsolo zokushoda kwe-exocrine pancreatic. Kungase futhi kucelwe udokotela ukuthi athole izimbangela zenkinga yohudo olungapheli.

Ukunqunywa kwe-elastase ye-faecal kwenziwa ngesampula yendle. Isiguli singalanda isampula ekhaya laso nezinto ezinikezwa ilabhorethri yokuhlaziya ukwelashwa. Uzobe eseshiya ngokushesha isampula elabhorethri ukuze ihlaziywe. Isampula kufanele igcinwe ku-4 ° C (esiqandisini). Ukuhlaziywa kufanele kwenziwe phakathi kwamahora angu-48 wokuqoqwa kwendle. Lokhu ukuhlolwa kohlobo lwesemishi lwe-ELISA, oluqondene ne-elastase yomuntu (elastase E1). Lokhu kuhlola kuhlanganisa ukuhlukanisa iphrotheni phakathi kwamasosha omzimba amabili, ngalinye libona ucezu lweprotheni, ngaleyo ndlela kwenze kube nokwenzeka ukulibona nokubala.

Uma isiguli senezelwa nge-enzyme replacement therapy, lokhu akunawo umthelela esikalini se-fecal elastase. Ngokuphambene, izinto ezithile kufanele zigwenywe ngesonto langaphambi nangelanga lesampula:

• ukuhlolwa kwe-radiological yokugaya;
• amalungiselelo e-colonoscopy;
• ama-laxatives;
• ukugqoka kwamathumbu noma izidakamizwa zokulwa nesifo sohudo. Ngempela, lezi zakhi zingashintsha izitshalo zamathumbu noma zenze amanga imiphumela yokuhlaziywa.

Ngokufanayo, kuhle ukugwema, uma kungenzeka, lokhu kuhlolwa ngesikhathi sohudo olunzima. Uma lokhu kungenakwenzeka, kufanele kuboniswe ukuze udokotela akwazi ukukucabangela lapho ehlaziya imiphumela.

Izinga eliphansi kakhulu le-fecal elastase (ngaphandle kwesimo sohudo) libonisa ukungasebenzi kahle kwe-exocrine kumanyikwe. Ukuhlushwa okuphakathi kuka-150 no-200 µg/g kuyinkomba yokushoda okumaphakathi kwe-exocrine pancreatic. Sikhuluma ngokuntuleka okukhulu kwe-exocrine pancreatic lapho izinga le-fecal elastase lingaphansi kwe-15 μg / g.

Ukusuka lapho, udokotela uzodinga ukwenza ezinye izivivinyo, izivivinyo kanye nezithombe ukuze athole imbangela yalokhu kungasebenzi. Maningi amathuba:

• i-pancreatitis engapheli;
• i-pancreatitis enamandla;
• i-cystic fibrosis;
• isifo sikashukela;
• isifo se-celiac;
• Isifo sikaCrohn;
• I-Zollinger-Ellison syndrome;
• ukuhlinzwa kwendlela yokugaya ephezulu;
• njll