Okuqukethwe
Ngokuvumelana nomsebenzi walo, Ibhodi Lokuhlela le-MedTvoiLokony lenza yonke imizamo yokuhlinzeka ngokuqukethwe kwezokwelapha okuthembekile okusekelwa ulwazi lwakamuva lwesayensi. Ifulegi elengeziwe elithi "Okuqukethwe Okuhloliwe" libonisa ukuthi i-athikili ibuyekezwe noma yabhalwa udokotela ngokuqondile. Lokhu kuqinisekisa okuyizinyathelo ezimbili: intatheli yezokwelapha kanye nodokotela basivumela ukuthi sinikeze okuqukethwe kwekhwalithi ephezulu ngokuhambisana nolwazi lwamanje lwezokwelapha.
Ukuzibophezela kwethu kule ndawo kuye kwathakaselwa, phakathi kokunye, yiNhlangano Yezintatheli Zezempilo, eyaklomelisa Ibhodi Lokuhlela le-MedTvoiLokony ngesihloko sokuhlonipha esithi Umfundisi Omkhulu.
I-Diaprel (i-glycoside) umuthi wesifo sikashukela somlomo. Isesimweni samaphilisi okukhululwa ashintshiwe. I-Diaprel yehlisa amazinga kashukela egazini futhi ibangele ukukhululwa kwe-insulin. Isithako esisebenzayo ku-Diaprel yi-gliclazide.
Isebenza kanjani i-Diaprel?
i-diaprel ikhuthaza ukukhululwa kwe-insulin egazini futhi yehlise amazinga eglucose. Isetshenziselwa ukwelapha isifo sikashukela sohlobo 2 (isifo sikashukela esingancike ku-insulin). I-Gliclazide okwamanje ku I-Diaprelu ibophezela kuphrotheni ye-membrane yamaseli e-beta ku-pancreas, okuvumela ukuthi umzila we-potassium uvalwe, iziteshi ze-calcium zivuleke kanye nama-ion e-calcium agelezele engqamuzaneni. Lokhu, futhi, kubonisa ukukhiqizwa nokukhululwa kwe-insulin. I-Gliclazide imuncwa kahle emgudwini wesisu, umphumela wayo uhlala emahoreni ayi-6 kuye kwayi-12. Ibe isikhishwa emchamweni.
Izinkomba zokusetshenziswa kwe-Diaprel
i-diaprel isetshenziswa ekwelapheni isifo sikashukela esingancike ku-insulin (uhlobo lwesifo sikashukela sohlobo 2) lapho ukudla okwanele, ukuncipha kwesisindo kanye nokwelapha ngokuzivocavoca kunganele ukugcina amazinga eglucose egazi ajwayelekile.
Contraindications ukusetshenziswa kwe-Diaprel
i-diaprel akufanele kube njalo isetshenzisiwe uma i-allergic noma i-hypersensitive ku-sulfonamides noma i-sulfonylurea derivatives, kanye nalapho isiguli siguliswa kunoma yisiphi esinye isithako somuthi. Akufanele sebenzisa i-Diaprelu ukwelapha isifo sikashukela sohlobo 1 (esincike ku-insulin), ku-pre-coma noma i-coma yesifo sikashukela, ku-ketoacidosis yesifo sikashukela, ukukhubazeka okukhulu kwezinso noma kwesibindi nalapho kusetshenziswa i-miconazole.
I-contraindication ekusetshenzisweni kwe-Diaprel ukukhulelwa nokuncelisa.
Gcina ukuqapha okukhulungokufaka isicelo i-diaprel lapho isiguli singakudli njalo ukudla (lokhu kungase kubangele i-hypoglycemia, okungukuthi ukwehla okukhulu kwamazinga kashukela egazini). Ukusetshenziswa kwama-carbohydrate (ushukela) ngesikhathi sokwelashwa kwezidakamizwa i-diaprel kufanele kube okwanele emsebenzini kanye nomzamo womzimba owenziwe isiguli - izinga likashukela akufanele livunyelwe ukuba liwele ngaphansi kwesimiso. I-contraindication ukusetshenziswa I-Diaprelu kukhona futhi ukusetshenziswa ngokweqile utshwala kanye nokusetshenziswa okufanayo kwezinye izidakamizwa.
Imiphumela emibi lapho uthatha i-Diaprel
i-diaprel cishe njenganoma yimuphi umuthi ingayenga uchungechunge imiphumela emibi kanye nemiphumela emibi. Lokhu kufaka, ikakhulukazi, izimpawu ze-hypoglycemia (i-hypoglycemia) njengekhanda elibuhlungu, indlala, isicanucanu, ukuhlanza, ukukhathala nokukhathala, ukozela, ukuphazamiseka kokulala, ukungahlaliseki, ukuphazamiseka kokuhlushwa, ulaka, ukudangala, ukudideka, ukwanda kwesikhathi sokuphendula, ukuncipha kokuqaphela, ukuphazamiseka kwezinzwa, isiyezi, ukuthuthumela kwemisipha, ukudangala, ukuquleka, ukulahlekelwa ukwazi, izinkinga zokuphefumula, ukwehla kwenhliziyo, ukujuluka, ukushaya kwenhliziyo, ukukhathazeka, ukushaya kwenhliziyo okukhuphukayo, umfutho wegazi ophakeme, isikhumba esimanzi, i-paresis yezitho. I-Hypoglycemia enzima ingase ifane nezimpawu ze-stroke. Kufanele unikeze isiguli ushukela (ama-carbohydrate) bese ubonana nodokotela. Qaphela ukuthi ukudla nokuzivocavoca kunomthelela emazingeni kashukela egazini, ngakho-ke umthamo I-Diaprelu kufanele kukhethwe ngakunye futhi kungase kushintshe.