I-Purpura fulminans yisifo esithathelwanayo esimelela uhlobo olubi kakhulu lwe-sepsis. Ibangela ukujiya kwegazi kanye ne-necrosis yezicubu. Ivamise ukubangelwa ukutheleleka kwe-meningococcal futhi umphumela wayo uyabulala uma unganakekelwa ngesikhathi.

Ukushisa okuphezulu, ukukhubazeka okujulile kwesimo esijwayelekile, ukuhlanza kanye nobuhlungu besisu yizimpawu zokuqala ezingenasici. Ichashaza elilodwa noma amaningi abomvu nokunsomi asakazeka ngokushesha esikhumbeni, ngokuvamile ezithweni ezingezansi. Lesi yi-purpura, isilonda esophayo esikhumbeni. Ukucindezela esikhumbeni akuchithi igazi futhi akwenzi ukuthi ibala linyamalale okwesikhashana, isibonakaliso sokuthi "i-extravasation" yegazi ezicubu. Lokhu kungenxa yokuthi i-Purpura Fulminans ibangela ukuhanjiswa kwe-intravascular coagulation (DIC), okuwukwakheka kwamahlule amancane azophazamisa ukugeleza kwegazi (i-thrombosis), aliqondise ku-dermis futhi abangele ukopha kanye necrosis yezicubu zesikhumba. Isifo esithathelwanayo singahambisana nesimo sokushaqeka noma ukuphazamiseka kokuqaphela komuntu othintekile.

Ezimweni eziningi, i-purpura fulminans ixhunyaniswa nokutheleleka kwebhaktheriya okuhlaselayo futhi okunzima. I-Neisseria meningitidis (i-meningococcus) iyi-ejenti ethelelanayo evame kakhulu ehilelekile, ibalwa cishe ku-75% wamacala. Ingozi yokuthola i-purpura fulminans ivela ku-30% wezifo ezihlaselayo ze-meningococcal (IIMs). (2) Ikesi elingu-1 kuya kwezi-2 le-IMD kubahlali abayi-100 liyenzeka unyaka ngamunye e-France, ngenani lokufa kwabantu elicishe libe ngu-000%. (10)

Amanye ama-bacterial agents angase abe nesibopho sokuthuthukiswa kwe-purpura fulminans, njenge Streptococcus pneumoniae (i-pneumococcus) noma I-Haemophilus influenzae (i-bacillus kaPfeiffer). Ngezinye izikhathi imbangela iwukuntuleka kweprotheni C noma i-S, edlala indima ekuhlanganiseni, ngenxa yokungajwayelekile kwezakhi zofuzo: ukuguqulwa kofuzo lwe-PROS1 (3q11-q11.2) ku-protein C kanye ne-PROC gene (2q13-q14) kuphrotheni C. Kufanele kuqashelwe ukuthi i-purpura fulgurans ingabangela ukutheleleka okuncane okufana nenkukhu, ezimweni ezingavamile kakhulu.

I-Purpura fulminans ingathinta noma iyiphi iminyaka, kodwa izingane ezisanda kuzalwa ezingaphansi kweminyaka engu-15 kanye nentsha eneminyaka engu-20 kuya ko-1 ubudala zisengozini enkulu. (XNUMX) Abantu abebesondelene kakhulu nesisulu sokushaqeka kwe-septic kufanele bathole ukwelashwa kwe-prophylactic ukuvikela noma iyiphi ingozi yokutheleleka.

I-prognosis ixhumene ngqo nesikhathi esithathiwe ukuthatha izintambo. I-Purpura fulminans imele ngempela isimo somtholampilo sokuphuthuma okwedlulele esidinga ukwelashwa ngama-antibiotic kusenesikhathi, ngaphandle kokulinda ukuqinisekiswa kokuxilongwa futhi kungabi ngaphansi kwemiphumela yokuqala yesiko legazi noma ukuhlolwa kwegazi. I-purpura ehlanganisa okungenani indawo eyodwa enobubanzi obungaphezulu noma obulingana namamilimitha angu-3, ​​kufanele iqalise ngokushesha isexwayiso nokwelashwa. Ukwelashwa ngama-antibiotic kufanele kube ngokufanele ukutheleleka kwe-meningococcal futhi kwenziwe nge-intravenously noma, ukwehluleka lokho, nge-intramuscularly.